ArticleNature communications2022
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Illuminating aging with multimodal optical metabolic imaging.Science advances · 2026Review
- Cancer-associated fibroblasts drive metabolic heterogeneity in colorectal cancer cells: predictions from metabolic modeling.NPJ systems biology and applications · 2026Article
- Intestinal lactate as a crucial molecular for intestinal epithelial cell renewal in sepsis.Critical care (London, England) · 2025Article
- Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells.Nature metabolism · 2025Article
- Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases.Journal of physiology and biochemistry · 2025Review
- Dietary and metabolic effects on intestinal stem cells in health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- The emerging role of intestinal stem cells in ulcerative colitis.Frontiers in medicine · 2025Review
- Development of a Dual Reporter System to Simultaneously Visualize CaACS sensors · 2024Article
- Is Cancer Metabolism an Atavism?Cancers · 2024Review
- Fer-1 Protects against Isoflurane-Induced Ferroptosis in Astrocytes and Cognitive Impairment in Neonatal Mice.Neurotoxicity research · 2024Article
- SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis.Cell reports · 2024Article
- Modification patterns and metabolic characteristics of mHeliyon · 2024Article
- Interplay between epigenetics and metabolism controls cancer stem cell plasticity.Frontiers in epigenetics and epigenomics · 2024Review
- Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2.Cell death & disease · 2023Article
- MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.iScience · 2023Article
- The Role of Regulatory T Cells in Cancer Treatment Resistance.International journal of molecular sciences · 2023Review
- Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging.Analytical chemistry · 2023Article
- Exploring the Influence of Age, Gender and Body Mass Index on Colorectal Cancer Location.Medicina (Kaunas, Lithuania) · 2023Article
- Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming.Cancers · 2023Article
- Immunometabolic reprogramming, another cancer hallmark.Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 7 institutions in 4 countries.
Carlos SebastianCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy. csebastian@ub.edu.ORCID 0000-0001-6623-8028
Christina FerrerThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Maria SerraCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.
Jee-Eun ChoiThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Nadia DucanoCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.
Alessia MiraCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.
Manasvi S ShahDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Sylwia A StopkaDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Andrew J PerciaccanteDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8698-9651
Claudio IsellaCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.
Daniel Moya-RullCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.ORCID 0000-0002-3555-6477
Marianela Vara-MesslerDepartment of Oncology, University of Torino, Turin, Italy.
Silvia GiordanoCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.ORCID 0000-0003-1854-1086
Elena MaldiCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.ORCID 0000-0002-8094-820X
Niyati DesaiDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Diane E CapenCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0001-7254-788X
Enzo MedicoCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.
Murat CetinbasDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Ruslan I SadreyevDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Dennis BrownCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Miguel N RiveraThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Anna SapinoCandiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.ORCID 0000-0003-3542-9571
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0002-0402-4857
Nathalie Y R AgarDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3149-3146
Raul MostoslavskyThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.ORCID 0000-0002-7740-5212
Candiolo Cancer Institute · ITHarvard University · USBrigham and Women's Hospital · USBoston Children's Hospital · USBroad Institute · USDirectorate-General Joint Research Centre · BEInstitut Botànic de Barcelona · ES
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MSTRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4MTRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Carl-Fredrik Westin · 2021 to 2026
$10.7MTrans Network ProjectU54CA210180 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WHITE, FOREST M · 2016 to 2020
$10.2MMechanistic Understanding for the Role of Lin28b in Pancreatic Cancer ProgressionR01CA235412 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI EL-BARDEESY, NABEEL, MOSTOSLAVSKY, RAUL · 2019 to 2023
$3.2MThe Role of SIRT6 and Metabolism in APC Mediated TumorigenesisR01CA175727 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MOSTOSLAVSKY, GUSTAVO, MOSTOSLAVSKY, RAUL · 2014 to 2018
$2.6MRegulation of the Intestinal Stem Cells During RegenerationR01DK119488 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI BREAULT, DAVID T · 2019 to 2022
$1.9MThe histone deacetylase SIRT6 modulates Transcriptional pausingR01GM128448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSTOSLAVSKY, RAUL · 2019 to 2022
$1.6MTraining in Image Guidance, Precision Diagnosis and TherapyT32EB025823 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Fiona Fennessy, Lauren Jean O'Donnell · 2019 to 2026
$1.5MRole of Gstt1 in metastatic maintenance and self-renewal in PDAR00CA252600 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FERRER, CHRISTINA · 2022 to 2024
$747kNCI NIH HHS K99 CA252600NCI NIH HHS R00 CA252600NCI NIH HHS R01 CA175727NCI NIH HHS R01 CA235412NCI NIH HHS R21 CA120342NCI NIH HHS U54 CA210180NIBIB NIH HHS P41 EB028741NIBIB NIH HHS T32 EB025823NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK119488NIGMS NIH HHS R01 GM128448
Abstract
Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylase SIRT6 regulates tumor initiation during intestinal cancer by controlling glucose metabolism. Loss of SIRT6 results in an increase in the number of intestinal stem cells (ISCs), which translates into enhanced tumor initiating potential in APC
Indexed as
NeoplasmsSirtuinsAnimalsCell Transformation, NeoplasticGlycolysisIntestinesMicePyruvate Dehydrogenase Acetyl-Transferring KinasePyruvate Dehydrogenase Acetyl-Transferring KinaseSirt6 protein, mouseSirtuins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.