ArticleNature communications2022
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers.
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182citing papers in PubMed
18.6field-weighted citation impact, top 1% of its field
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Who cites it
182 citing papers in PubMed, 234 citations in OpenAlex.
- Plasma lipidomic and metabolomic profiles in high-grade glioma patients before and after 72-h presurgery water-only fasting.Molecular oncology · 2025Trial
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Functional deficiency of circadian regulator PER2 enhances breast cancer susceptibility and progression with immunosuppression.Oncogene · 2026Article
- Propionyl-CoA catabolism is a metabolic gatekeeper for fatty acid oxidation in pancreatic cancer.Oncogene · 2026Article
- Immune checkpoints and immunoregulation in metabolic diseases and cancers: pathological mechanisms and therapeutic potential.Signal transduction and targeted therapy · 2026Review
- Gastric cancer tertiary lymphoid structures in the muscularis propria are associated with therapy resistance and promote immunosuppression.Nature communications · 2026Article
- Chemotherapy-Activated GSK3β-DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Alantolactone inhibits T-cell lymphoma progression by suppressing CD47 expression via the PI3K/AKT and ERK signaling pathways.Apoptosis : an international journal on programmed cell death · 2026Article
- Construction Strategies, Microenvironmental Modelling and Precision-Therapy Applications of Glioma Organoid Models.Cancers · 2026Review
- Fatty Acid Metabolism Rewires Glioblastoma Progression and Treg-Mediated Immune Resistance.Cancers · 2026Review
- Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Unsaturated/Saturated Fatty Acid Ratio: A Metabolic Hub and Therapeutic Vulnerability in Glioblastoma.Biomedicines · 2026Review
- GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM).Cell death and differentiation · 2026Article
- Targeting the CD47-SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next-generation therapeutic strategies.Smart molecules : open access · 2026Review
- Tumor-derived PCSK9-enriched exosomes reprogram adipocytes to drive metabolic dysregulation and immune evasion in triple-negative breast cancer.Cell death & disease · 2026Article
- An Extravascular Synergistic Cocktail Therapeutic Strategy Based on Lanifibranor Loaded Self-Healing Bioelastomer for Abdominal Aortic Aneurysms.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- FLASH Radiotherapy and Organelle-Targeted Radiosensitization in Glioblastoma: A Conceptual and Translational Review.Cancers · 2026Review
- Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application.MedComm · 2026Review
- Status and trends in glioblastoma lipid metabolism research: a bibliometric analysis.Discover oncology · 2026Review
- CPT1A drives cisplatin resistance via acetylation‑dependent activation of DRP1 and mitochondrial fission in small cell lung cancer.Cell death & disease · 2026Article
122 more citing papers are in PubMed but not listed here.
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Authors and funding
29 authors at 7 institutions in 3 countries.
Nian JiangDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Bowen XieDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Wenwu XiaoDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA, 95817, USA.
Ming FanDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Shanxiu XuDepartment of Surgery, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
Yixin DuanDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Yamah HamsafarDepartment of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, 95817, USA.
Angela C EvansDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Jie HuangDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Weibing ZhouDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Xuelei LinDepartment of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
Ningrong YeDepartment of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
Siyi WanggouDepartment of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
Wen ChenDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Di JingDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA, 95817, USA.
Ruben C FragosoDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Brittany N DuggerDepartment of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, 95817, USA.
Paul F WilsonDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Matthew A ColemanDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Shuli XiaDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Xuejun LiDepartment of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
Lun-Quan SunCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.ORCID http://orcid.org/0000-0002-0558-5250
Arta M MonjazebDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Aijun WangDepartment of Surgery, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.ORCID http://orcid.org/0000-0002-2985-3627
William J MurphyNCI-Designated Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA.ORCID http://orcid.org/0000-0002-2793-401X
Hsing-Jien KungDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA, 95817, USA.
Kit S LamDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA, 95817, USA.ORCID http://orcid.org/0000-0002-3076-6969
Hong-Wu ChenDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA, 95817, USA.ORCID http://orcid.org/0000-0003-0177-6989
Jian Jian LiDepartment of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA. jijli@ucdavis.edu.ORCID http://orcid.org/0000-0003-3694-9675
University of California, Davis · USCentral South University · CNJohns Hopkins University · USTaipei Medical University · TWUniversity of California Davis Medical Center · USUniversity of California System · USVA Northern California Health Care System · US
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9MTherapeutic targeting of orphan NR in ER-negative breast cancerR01CA224900 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, HONGWU · 2019 to 2023
$2.1MMitochondrial bioenergetics is associated with aggressive breast cancer growthR01CA213830 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LI, JIAN JIAN · 2017 to 2021
$1.8MTherapeutic targeting of tumor metabolism in advanced prostate cancerI01BX004271 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI CHEN, HONGWU · 2019 to 2025
–BLRD VA I01 BX004271NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA213830NCI NIH HHS R01 CA224900
Abstract
Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes (CPT1A, CPT2 and ACAD9) and immune checkpoint CD47 is dominant in recurrent GBM patients with poor prognosis. A glycolysis-to-FAO metabolic rewiring is associated with CD47 anti-phagocytosis in radioresistant GBM cells and regrown GBM after radiation in syngeneic mice. Inhibition of FAO by CPT1 inhibitor etomoxir or CRISPR-generated CPT1A
Indexed as
CD47 AntigenGlioblastomaAnimalsCell Line, TumorFatty AcidsHumansImmune EvasionMicePhagocytosisCD47 AntigenCD47 protein, humanFatty Acids
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.