Evidence map›Paper›PMID 35314501›Full record

Observational studyNeurology2022

Simplified Edinburgh CT Criteria for Identification of Lobar Intracerebral Hemorrhage Associated With Cerebral Amyloid Angiopathy.

Jochen A Sembill, Michael Knott, Mingming Xu, Sebastian S Roeder, Manuel Hagen, Maximilian I Sprügel, Anne Mrochen, Matthias Borutta, Philip Hoelter, Tobias Engelhorn and 3 more

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03183167 (Universitätsklinikum Erlangen Cohort of Patients With Spontaneous Intracerebral Hemorrhage), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03183167 completednot on this map

Universitätsklinikum Erlangen Cohort of Patients With Spontaneous Intracerebral Hemorrhage

TypeobservationalSponsorUniversity of Erlangen-Nürnberg Medical SchoolRan2006 to 2017Enrolled1,076ConditionsSpontaneous Intracerebral HemorrhageArmsNo intervention
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Clinical Management of Cerebral Amyloid Angiopathy.Journal of clinical medicine · 2025
    Review
  8. Review
  9. Association ofStroke and vascular neurology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Fluid biomarkers in cerebral amyloid angiopathy.Frontiers in neuroscience · 2024
    Review
  14. Review
  15. Article
  16. Intracerebral haemorrhage.Nature reviews. Disease primers · 2023
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Jochen A SembillFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Michael KnottFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Mingming XuFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Sebastian S RoederFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Manuel HagenFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Maximilian I SprügelFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Anne MrochenFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Matthias BoruttaFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Philip HoelterFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.ORCID 0000-0001-9768-9630
Tobias EngelhornFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Veit RothhammerFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Kosmas MachaFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.
Joji B KuramatsuFrom the Departments of Neurology (J.A.S., S.S.R., M.H., M.I.S., A.M., M.B., V.R., K.M., J.B.K.) and Neuroradiology (M.K., P.H., T.E.), University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany; and Department of Neurology (M.X.), Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, China.ORCID 0000-0002-7630-7880
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn patients with lobar intracerebral hemorrhage (ICH), etiologic characterization represents a tradeoff between feasibility, resource allocation, and diagnostic certainty. This study investigated the accuracy and clinical utility of the simplified Edinburgh CT criteria to identify underlying cerebral amyloid angiopathy (CAA).

methodsThis external validation analyzed 210 consecutive patients with lobar ICH and available CT and MRI studies from a prospective single-center observational cohort study (2006-2015, Longitudinal Cohort Study on ICH Care [UKER-ICH,] NCT03183167). We investigated the interrater variability and diagnostic accuracy of the simplified Edinburgh CT-based criteria for identification of ICH associated with probable CAA according to MRI-based modified Boston criteria as a reference standard. We evaluated the utility of the simplified Edinburgh criteria by decision curve analysis, comparing the theoretical clinical net benefit (weighted benefit-harm at varying threshold probabilities) of the high-risk category (finger-like projections and subarachnoid hemorrhage) for ruling in and the low-risk category (neither finger-like projections nor subarachnoid hemorrhage) for ruling out with the assumptions of no or all patients having CAA (default strategies).

resultsOf 210 patients, 70 (33.3%) had high risk, 67 (31.9%) had medium risk, and 73 (34.8%) had low risk for CAA-associated ICH according to simplified Edinburgh CT criteria, showing moderate interrater variability. Discrimination was good (area under the receiver operating characteristics curve 0.74, 95% CI 0.67-0.81) without evidence of poor calibration (Hosmer-Lemeshow, DISCUSSION: Applying the simplified Edinburgh CT criteria during diagnostic workup seems clinically useful and may accurately identify CAA in patients with lobar ICH. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov Identifier: NCT03183167. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in patients with lobar hemorrhages, the simplified Edinburgh criteria accurately identify those at high risk of CAA.

Indexed as

Cerebral Amyloid AngiopathySubarachnoid HemorrhageCerebral HemorrhageHumansLongitudinal StudiesMagnetic Resonance ImagingProspective StudiesTomography, X-Ray Computed

Identifiers

PMID35314501
OpenAlexW4221063580

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.