ArticleNeurology(R) neuroimmunology & neuroinflammation2022
Diabetes Mellitus Is a Possible Risk Factor for Nodo-paranodopathy With Antiparanodal Autoantibodies.
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
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6 citing papers in PubMed, 4 citations in OpenAlex.
- Specific HLA-DRB1 Alleles Associate With Anti-Caspr1 and Anti-CNTN1 Autoantibodies in Autoimmune Nodopathies.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- A Next-Generation ELISA for the Detection of Anti-(Para)Nodal Antibodies in Autoimmune Nodopathy and COVID-19 Vaccinated Individuals.Journal of the peripheral nervous system : JPNS · 2026Article
- Distinct Epitopes Are Associated With Clinical Phenotypes in Autoimmune Nodopathies With Anti-Contactin1 Autoantibodies.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody.Internal medicine (Tokyo, Japan) · 2023Article
- Article
- Different binding and pathogenic effect of neurofascin and contactin-1 autoantibodies in autoimmune nodopathies.Frontiers in immunology · 2023Article
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Authors and funding
25 authors at 2 institutions in 2 countries.
Luise AppeltshauserFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.ORCID 0000-0001-5248-4009
Julia MessingerFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Katharina StarzFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
David HeinrichFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Anna-Michelle BrunderFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Helena StengelFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Bianca FiebigFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Ilya AyzenbergFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Frank BirkleinFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.ORCID 0000-0002-6672-4226
Christian DreselFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Johannes DorstFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Florian DvorakFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Alexander GrimmFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Alexander JoerkFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Frank LeypoldtFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Mathias MäurerFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Patrick MerlFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Sebastian MichelsFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.ORCID 0000-0002-9265-9034
Kalliopi PitarokoiliFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Mathias RosenfeldtFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Anne-Dorte SperfeldFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Marc WeihrauchFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Gabriel Simon WelteFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.
Claudia SommerFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.ORCID 0000-0002-7064-5002
Kathrin DopplerFrom the Department of Neurology (L.A., J.M., K.S., D.H., A.-M.B., H.S., B.F., C.S., K.D.), University Hospital of Würzburg; Department of Neurology (I.A., K.P.), St. Josef Hospital Bochum, Ruhr University of Bochum, Germany; Department of Neurology (I.A.), I.M. Sechenov First Moscow State Medical University, Russia; Department of Neurology (F.B., C.D.), University Medical Center of the Johannes Gutenberg University, Mainz; Department of Neurology (J.D., S.M.), University Hospital Ulm; German Center for Neurodegenerative Diseases (DZNE) (J.D.), Ulm; Department of Neurologic Rehabilitation (F.D.), Asklepios Schloßberg-Klinik, Bad König; Department of Neurology (A.G.), Tübingen University Hospital; Hans Berger Department of Neurology (A.J.), Jena University Hospital; Neuroimmunology Section (F.L.), Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel/Lübeck; Department of Neurology (F.L.), Kiel University; Department of Neurology (M.M.), Klinikum Würzburg Mitte gGmbH, Standort Juliusspital; Department of Neurology (P.M.), LVR-Klinik, Bonn; Department of Pathology (M.R.), Julius Maximilian University of Würzburg; Department of Neurology (A.-D.S.), Sächsisches Krankenhaus Altscherbitz, Schkeuditz; Department of Neurology (M.W.), Bundeswehrkrankenhaus Ulm; and Department of Neurology (G.S.W.), KRH Klinikum Nordstadt, Hannover, Germany.ORCID 0000-0003-2883-0009
Johannes Gutenberg University Mainz · DESechenov University · RU
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesNodo-paranodopathies are peripheral neuropathies with dysfunction of the node of Ranvier. Affected patients who are seropositive for antibodies against adhesion molecules like contactin-1 and neurofascin show distinct clinical features and a disruption of the paranodal complex. An axoglial dysjunction is also a characteristic finding of diabetic neuropathy. Here, we aim to investigate a possible association of antibody-mediated nodo-paranodopathy and diabetes mellitus (DM).
methodsWe retrospectively analyzed clinical data of 227 patients with chronic inflammatory demyelinating polyradiculoneuropathy and Guillain-Barré syndrome from multiple centers in Germany who had undergone diagnostic testing for antiparanodal antibodies targeting neurofascin-155, pan-neurofascin, contactin-1-associated protein 1, and contactin-1. To study possible direct pathogenic effects of antiparanodal antibodies, we performed immunofluorescence binding assays on human pancreatic tissue sections.
resultsThe frequency of DM was 33.3% in seropositive patients and thus higher compared with seronegative patients (14.1%, OR = 3.04, 95% CI = 1.31-6.80). The relative risk of DM in seropositive patients was 3.4-fold higher compared with the general German population. Seropositive patients with DM most frequently harbored anti-contactin-1 antibodies and had higher antibody titers than seropositive patients without DM. The diagnosis of DM preceded the onset of neuropathy in seropositive patients. No immunoreactivity of antiparanodal antibodies against pancreatic tissue was detected. DISCUSSION: We report an association of nodo-paranodopathy and DM. Our results suggest that DM may be a potential risk factor for predisposing to developing nodo-paranodopathy and argue against DM being induced by the autoantibodies. Our findings set the basis for further research investigating underlying immunopathogenetic connections.
Indexed as
Diabetes MellitusPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingAutoantibodiesHumansRanvier's NodesRetrospective StudiesRisk FactorsAutoantibodies
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