Evidence map›Paper›PMID 35314194›Full record

ArticleThe Journal of biological chemistry2022

Mycobacterium tuberculosis encodes a YhhN family membrane protein with lysoplasmalogenase activity that protects against toxic host lysolipids.

Marianne S Jurkowitz, Abul K Azad, Paula C Monsma, Tracy L Keiser, Jean Kanyo, TuKiet T Lam, Charles E Bell, Larry S Schlesinger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Marianne S JurkowitzDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, Ohio, USA. Electronic address: jurkowitz.1@osu.edu.
Abul K AzadHost Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Paula C MonsmaDepartment of Neuroscience, Ohio State University, Columbus, Ohio, USA.
Tracy L KeiserDepartment of Moleculaire Microbiologie, Vrije Universiteit, Amsterdam, the Netherlands.
Jean KanyoKeck MS & Proteomics Resource, Yale University, New Haven, Connecticut, USA.
TuKiet T LamKeck MS & Proteomics Resource, Yale University, New Haven, Connecticut, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.
Charles E BellDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, Ohio, USA; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA.
Larry S SchlesingerHost Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, USA. Electronic address: lschlesinger@txbiomed.org.
The Ohio State University · USTexas Biomedical Research Institute · USW. M. Keck Foundation · USVrije Universiteit Amsterdam · NL

Funding

TB and Innate Immune Regulation of Lung MacrophagesR01AI059639 · NIAID · OHIO STATE UNIVERSITY · PI SCHLESINGER, LARRY S. · 2005 to 2016
$3.2M
Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2017 to 2020
$1.9M
Nano-UPLC LTQ-Orbitrap Velos MS System for Yale University Keck LaboratoryS10RR031795 · NCRR · YALE UNIVERSITY · PI GULCICEK, EROL E · 2011 to 2011
$600k
A spinning disk confocal microscope for live-cell imagingS10OD010383 · OD · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2012 to 2012
$600k
TB and Innate Immune Regulation of Lung MacrophagesR21AI059639 · NIAID · OHIO STATE UNIVERSITY · PI SCHLESINGER, LARRY S. · 2004 to 2004
$299k
NCRR NIH HHS S10 RR031795NIAID NIH HHS R01 AI059639NIAID NIH HHS R21 AI059639NIH HHS S10 OD010383NINDS NIH HHS P30 NS104177
6 · The paper itself

Abstract

The pathogen Mycobacterium tuberculosis (M.tb) resides in human macrophages, wherein it exploits host lipids for survival. However, little is known about the interaction between M.tb and macrophage plasmalogens, a subclass of glycerophospholipids with a vinyl ether bond at the sn-1 position of the glycerol backbone. Lysoplasmalogens, produced from plasmalogens by hydrolysis at the sn-2 carbon by phospholipase A

Indexed as

HydrolasesMembrane ProteinsMycobacterium tuberculosisHumansLysophosphatidylcholinesLysophospholipidsMacrophagesMycobacterium smegmatisPlasmalogensHydrolasesLysophosphatidylcholineslysophosphatidylethanolamineLysophospholipidslysoplasmalogenaselysoplasmalogensMembrane ProteinsPlasmalogenscell injury and protectioncell wall–deficientlysoplasmalogenaselysoplasmalogen/lysophospholipidmacrophageMycobacterium smegmatisMycobacterium tuberculosis Rv1401 genephospholipase AspheroplastsYhhN protein

Identifiers

PMID35314194
PMCPMC9052158
OpenAlexW4220968578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.