ArticleGynecologic oncology2022
Impact of Obesity on Sentinel Lymph Node Mapping in Patients with apparent Early-Stage Endometrial Cancer: The ObeLyX study.
Article in Gynecologic oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07462663 (SHAPE-ENDO), which is not on this map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SHAPE-ENDO (Strategic Hormonal Approach & Prehabilitation in Endometrial Cancer): An Open-Label, Pilot Randomized Clinical Trial Comparing Standard Immediate Surgery Versus a Multimodal Metabolic Optimization and Prehabilitation Strategy Before Surgery in Patients With Atypical Endometrial Hyperplasia or Low-Risk Endometrioid Endometrial Cancer and BMI ≥40 kg/m²
Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Computer-assisted and image-guided surgery for surgical lymph-nodal staging of gynecologic cancer in the era of digital and robotic surgery: a review of current evidence.EClinicalMedicine · 2026Review
- From Avoiding Empty Packets to Real-Time Diagnosis: The Value of Robotic Ultrasound-Guided Surgery in Sentinel Lymph Node Dissection.Annals of surgical oncology · 2026Article
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- Sentinel lymph node and operative outcomes in patients with endometrial cancer and a BMI ≥ 50: the SLOPE-50 study.Journal of robotic surgery · 2026Article
- Predictors of sentinel lymph node mapping failure in endometrial cancer: a retrospective multicenter study.Frontiers in oncology · 2026Article
- Retroperitoneal vNOTES approach in early-stage endometrial cancer: a feasibility cohort with a contemporaneous laparoscopic comparison.BMC surgery · 2025Article
- Article
- Advanced robotic surgery in obese patients with gynecological cancers: tips and tricks from literature to clinical practice.Journal of robotic surgery · 2025Review
- Microscopic assessment of lymph node status in gynecological malignancies using full-field optical coherence tomography.Scientific reports · 2025Article
- Analysis of Sentinel Lymph Node Adoption Compared to Systematic Lymphadenectomy in Staging Early Endometrial Cancer at a Tertiary Center: An Ambispective Study.Journal of surgical oncology · 2025Article
- Article
- Comparison of laparoscopic vs. robotic sentinel lymph node mapping and biopsy in endometrial cancer.Journal of robotic surgery · 2025Article
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- Article
- Enhancing Sentinel Lymph Node Biopsy in Endometrial Cancer Using Augmented and Mixed Reality.Cureus · 2025Article
- Analysis of Predictive Factors Associated with Unsuccessful Sentinel Lymph Node Mapping in Endometrial Carcinoma.Cancers · 2024Article
- Article
- Parameters that may affect detection rates of SLN in morbidly obese patients with endometrial cancer and changes in everyday practice.Journal of robotic surgery · 2023Article
- Analysis of the disease burden trend of malignant tumors of the female reproductive system in China from 2006 to 2020.BMC women's health · 2022Article
- Predictive models for overall survival in breast cancer patients with a second primary malignancy: a real-world study in Shanghai, China.BMC women's health · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveConflicting data exists on the impact of Body Mass Index (BMI) on sentinel lymph-node (SLN) detection. The primary study endpoint was to investigate the impact of obesity on overall detection rate, bilateral mapping, and mapping failure rate of SLN. In addition, we evaluated possible differences in terms of surgical management and "empty-packet dissection" rate among obese and non-obese patients.
methodsMulticenter, propensity-matched, retrospective study. Patients with apparent early-stage endometrial cancer were included. Study population was divided into women with BMI </≥ 30 (Group-1 and Group-2). To lower the selection bias, a propensity-matched analysis was performed. Matching was based on histotype (endometrioid vs non-endometrioid), age (</≥65 years old), and presence of lymph-vascular space invasion.
resultsEight-hundred forty-four women were enrolled. After a 1:1 propensity-matched analysis, 764 patients were identified (Group-1 n = 382, Group-2 n = 382). A 1.156-fold increase in the risk of mapping failure for every 5 units of BMI increase was found (OR 1.156, 95% CI 1.033-1.294, p = 0.012), with a consequently decrease in bilateral mapping and overall detection rate (respectively OR 0.865, 95% CI 0.773-0.968, p = 0.012 and OR 0.785, 95% CI 0.670-0.920, p = 0.003). Obese patients were surgically under-staged in 9.4% of cases and showed an 8.2% of empty packet dissection (surgical under-staging: 5.0% vs 9.4%, p = 0.017; empty-packet dissection: 3.9% vs 8.2%, p = 0.022).
conclusionsBMI was confirmed as a statistically relevant predictor of mapping failure and decreased overall detection rate. In addition, obese women had a significantly higher odds of empty packet dissection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.