Evidence map›Paper›PMID 35313917›Full record

ArticleJournal of neuroinflammation2022

The innate immune receptor Nlrp12 suppresses autoimmunity to the retina.

Ellen J Lee, Ruth J Napier, Emily E Vance, Sydney J Lashley, Agnieszka D Truax, Jenny P Ting, Holly L Rosenzweig

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Anti-inflammatory mechanisms ofInternational journal of ophthalmology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ellen J LeeVA Portland Health Care System, Portland, OR, USA.
Ruth J NapierVA Portland Health Care System, Portland, OR, USA.
Emily E VanceVA Portland Health Care System, Portland, OR, USA.
Sydney J LashleyVA Portland Health Care System, Portland, OR, USA.
Agnieszka D TruaxLineberger Comprehensive Cancer Center, University North Carolina, Chapel Hill, NC, USA.
Jenny P TingLineberger Comprehensive Cancer Center, Depts. Genetics and Microbiology-Immunology, University of North Carolina, Chapel Hill, NC, USA.
Holly L RosenzweigVA Portland Health Care System, Portland, OR, USA. rosenzwh@ohsu.edu.ORCID http://orcid.org/0000-0002-5636-1134
Oregon Health & Science University · USUniversity of North Carolina at Chapel Hill · USVA Portland Health Care System · US

Funding

Innate Immunity and its integration in Autoimmune Disease of the EyeR01EY025250 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSENZWEIG, HOLLY LALLMAN · 2015 to 2023
$2.7M
Monarch/NLRP12: A Newly discovered Innate Immune Receptor in UveitisR21EY025039 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSENZWEIG, HOLLY LALLMAN · 2015 to 2016
$347k
Interaction of environment and genetics in the predisposition to inflammatory artI01BX002180 · VA · PORTLAND VA MEDICAL CENTER · PI ROSENZWEIG, HOLLY LALLMAN · 2014 to 2021
–
Reprogramming T Cells in Rheumatoid ArthritisIK2BX004523 · VA · PORTLAND VA MEDICAL CENTER · PI NAPIER, RUTH · 2019 to 2023
–
BLRD VA I01 BX002180BLRD VA IK2 BX004523NEI NIH HHS R01 EY025250NEI NIH HHS R21 EY025039NIH HHS EY025039NIH HHS EY025250u.s. department of veterans affairs I01BX002180
6 · The paper itself

Abstract

backgroundNod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined. The NLR, Nlrp12, has been reported to both inhibit and promote neuroinflammation in an animal model of multiple sclerosis (experimental autoimmune encephalomyelitis, EAE), where its T cell-specific role has been investigated. Uveitis resulting from autoimmunity of the neuroretina, an extension of the CNS, involves a breach in immune privilege and entry of T cells into the eye. Here, we examined the contribution of Nlrp12 in a T cell-mediated model of uveitis, experimental autoimmune uveitis (EAU).

methodsMice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 (IRBP

resultsNlrp12

conclusionsOur data identify a combinatorial role for Nlrp12 in dampening autoimmunity of the neuroretina. These findings could provide a pathway for development of therapies for uveitis and potentially other autoinflammatory/autoimmune diseases of the CNS.

Indexed as

Autoimmune DiseasesEncephalomyelitis, Autoimmune, ExperimentalUveitisAnimalsAutoimmunityDisease Models, AnimalEye ProteinsImmunity, InnateIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLRetinaRetinol-Binding ProteinsTh17 CellsEye ProteinsIntracellular Signaling Peptides and ProteinsNLRP12 protein, mouseRetinol-Binding ProteinsNlrp12Nod-like receptorPattern recognition receptorUveitis

Identifiers

PMID35313917
PMCPMC8939070
OpenAlexW4220811276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.