SynthesisJournal of orthopaedic surgery and research2022
Methods for bone quality assessment in human bone tissue: a systematic review.
Synthesis in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Effects of kaempferol on bone loss in animal models of osteoporosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Magnetic resonance imaging for jawbone assessment: a systematic review.Head & face medicine · 2024Pooled it
- Effect of walking and bone joint exercise on enhancing bone remodeling in menopausal women: A randomized controlled trial.Narra J · 2024Trial
- Automated Cortical Thickness Index Measurement in Pelvic Radiographs Using a Multi-Stage Deep Learning Framework.Journal of imaging informatics in medicine · 2026Article
- Intraoperative mechanical characterization of vertebral bone quality during percutaneous kyphoplasty.Mechanobiology in medicine · 2026Article
- Routine MRI Signal Intensity as a Surrogate of Subchondral Bone Healing: Validation Against Micro-CT and Histology in an Ovine Model.Diagnostics (Basel, Switzerland) · 2026Article
- Influence of cage material, plating and vertebral bone quality on subsidence and long-term outcomes following anterior cervical discectomy and fusion-a retrospective analysis.Journal of spine surgery (Hong Kong) · 2026Article
- Cross-Sectional Clinical Evaluation of Subantral Augmentation Using Nano Graft Composite: Implications for Implant Success.Dentistry journal · 2026Article
- Quantitative Ultrasound for the Assessment of Bone Quality in Hyperphenylalaninemia/Phenylketonuria Patients: Vitamin D Supplementation Versus No Supplementation.Metabolites · 2025Article
- Machine learning integration of multi-modal radiomics and clinical factors predicts refracture risk after percutaneous kyphoplasty in postmenopausal women.Scientific reports · 2025Article
- Emerging MRI-based spine scoring techniques targeting bone quality to assess osteoporosis, vertebral fracture risk, other spinal degenerative diseases, and post-surgical outcomes.La Radiologia medica · 2025Review
- Characteristics of changes in bone mineral density and body composition in obesity patients after metabolic and bariatric surgery: A prospective cohort study.Diabetes, obesity & metabolism · 2025Article
- Effect of L-thyroxine on bone biomechanical and morphometric parameters in rats.BMC veterinary research · 2025Article
- The Genetic and Biological Basis of Pseudoarthrosis in Fractures: Current Understanding and Future Directions.Diseases (Basel, Switzerland) · 2025Review
- Clinical Insights on Transforaminal Lumbar Interbody Fusion (TLIF) Implantations Following Spinal Fusion Surgery: Enhancing and Monitoring Bone Health in Patients.Orthopedic research and reviews · 2025Review
- Zinc valproic acid complex promotes osteoblast differentiation and exhibits anti-osteoporotic potential.Open life sciences · 2025Article
- A Novel Approach by Integrating CT-Based Imaging Data and Machine Learning to Predict Patient-Specific Young's Modulus Values.Advances in orthopedics · 2025Article
- Biomechanical perspectives on image-based hip fracture risk assessment: advances and challenges.Frontiers in endocrinology · 2025Review
- Hypoglycemic agents and bone health; an umbrella systematic review of the clinical trials' meta-analysis studies.Diabetology & metabolic syndrome · 2024Review
- The effects of simvastatin on the bone microstructure and mechanics of ovariectomized mice: a micro-CT and micro-finite element analysis study.BMC musculoskeletal disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor biomechanical investigations on bone or bone implants, bone quality represents an important potential bias. Several techniques for assessing bone quality have been described in the literature. This study aims to systematically summarize the methods currently available for assessing bone quality in human bone tissue, and to discuss the advantages and limitations of these techniques.
methodsA systematic review of the literature was carried out by searching the PubMed and Web of Science databases from January 2000 to April 2021. References will be screened and evaluated for eligibility by two independent reviewers as per PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies must apply to bone quality assessment with imaging techniques, mechanical testing modalities, and compositional characterization. The terms used for the systematic search were: "(bone quality". Ti,ab.) AND "(human bone specimens)".
resultsThe systematic review identified 502 relevant articles in total. Sixty-eight articles met the inclusion criteria. Among them, forty-seven articles investigated several imaging modalities, including radiography, dual-energy X-ray absorptiometry (DEXA), CT-based techniques, and MRI-based methods. Nineteen articles dealt with mechanical testing approaches, including traditional testing modalities and novel indentation techniques. Nine articles reported the correlation between bone quality and compositional characterization, such as degree of bone mineralization (DBM) and organic composition. A total of 2898 human cadaveric bone specimens were included.
conclusionsAdvanced techniques are playing an increasingly important role due to their multiple advantages, focusing on the assessment of bone morphology and microarchitecture. Non-invasive imaging modalities and mechanical testing techniques, as well as the assessment of bone composition, need to complement each other to provide comprehensive and ideal information on the bone quality of human bone specimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.