ArticleBMC medicine2022
The influence of childhood asthma on adult height: evidence from the UK Biobank.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Effects of long-term inhaled corticosteroids on growth velocity and adult height in children with asthma: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Growth and sleep outcomes after adenotonsillectomy in pediatric mild sleep-disordered breathing.Scientific reports · 2025Trial
- Associations of asthma with cardiometabolic diseases and multimorbidity: A cohort study in the UK Biobank.NPJ primary care respiratory medicine · 2025Article
- Impact of Childhood Tonsillectomy on Adult Height-A Study of the UK Biobank.Laryngoscope investigative otolaryngology · 2025Article
- Unveiling the Complexities of Pediatric Asthma Treatment: Evidence, Controversies, and Emerging Approaches.Paediatric drugs · 2025Review
- Atopic dermatitis in childhood and pubertal development: A nationwide cohort study.JAAD international · 2025Article
- Effects of urinary tract infection during the first years of life in subsequent growth: a nationwide comparative matched cohort study.Translational pediatrics · 2023Article
- Variants inFrontiers in genetics · 2023Article
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundTo elucidate the influence of childhood asthma on adult height after consideration of genetic heterogeneity in height.
methodsBased on the UK Biobank, we conducted a matched cohort study, including 13,602 European individuals with asthma diagnosed before 18 years old and 136,008 matched unexposed individuals without such an experience. Ascertainment of asthma was based on self-reported data (97.6%) or clinical diagnosis in healthcare registers (2.4%). We studied three height outcomes, including (1) the attained adult height (in centimeters), (2) the height deviation measured as the difference between a person's rank of genetically determined height (based on generated polygenetic risk score) and their rank of attained adult height in the study population (deviation in % of height order after standardization), and (3) the presence of height deficit comparing genetically determined and attained height (yes or no). We applied linear mixed-effect models to assess the associations of asthma diagnosed at different ages with attained adult height and height deviation, and conditional logistic regression models to estimate the associations of asthma with the risk of height deficit.
results40.07% (59,944/149,610) of the study participants were born before 1950, and most of them were men (57.65%). After controlling for multiple covariates, childhood asthma was associated with shorter attained adult height, irrespective of age at asthma diagnosis. However, in the analysis of height deviation (deviation in %), we observed the greatest height deviation among individuals with asthma diagnosed before 4 years of age (- 2.57 [95% CI - 4.14 to - 1.00] and - 2.80 [95% CI - 4.06 to - 1.54] for the age of ≤ 2 and 3-4 years, respectively). The magnitude of height deviation in relation to asthma declined thereafter and became null after age 6. Similarly, there was a statistically significant height deficit in relation to an asthma diagnosis at ages ≤ 2 and 3-4 (odds ratios = 1.21, 95% CI 1.04 to 1.40, and 1.15, 95% CI 1.02 to 1.29) but not thereafter. The result pattern was similar when separately analyzing asthma with or without inhaled glucocorticoid (ICS) use, despite that the estimates were consistently stronger among asthma individuals who used ICS.
conclusionsOur results suggest a notable association of childhood asthma, primarily asthma diagnosed at an early age, with adult height, after consideration of genetic heterogeneity in height and use of ICS. This finding highlights the need for surveillance on the growth problems among children with asthma.
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