Evidence map›Paper›PMID 35313765›Full record

ArticleJournal of investigative medicine high impact case reports

Pulmonary Tumor Embolism and Pulmonary Tumor Thrombotic Microangiopathy Causing Rapidly Progressive Respiratory Failure: A Case Series.

Kartikeya Rajdev, Ujjwal Madan, Sean McMillan, Kyle Wilson, Kurt Fisher, Ashley Hein, Amol Patil, Sabin Bista, Daniel Hershberger, Brian Boer

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Pulmonary Hypertension in the Field of Hematological and Oncological Diseases.Respiration; international review of thoracic diseases · 2025
    Review
  2. Review
  3. Clinical-radiological-pathological correlation in pulmonary hypertension with unclear and/or multifactorial mechanisms.European respiratory review : an official journal of the European Respiratory Society · 2023
    Article
  4. Article
  5. A Picture Is Worth 2,000 Words.JACC. CardioOncology · 2023
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Kartikeya RajdevUniversity of Nebraska Medical Center, Omaha, USA.
Ujjwal MadanUniversity College of Medical Sciences, Delhi, India.
Sean McMillanUniversity of Nebraska Medical Center, Omaha, USA.
Kyle WilsonUniversity of Nebraska Medical Center, Omaha, USA.
Kurt FisherUniversity of Nebraska Medical Center, Omaha, USA.ORCID https://orcid.org/0000-0002-8391-390X
Ashley HeinUniversity of Nebraska Medical Center, Omaha, USA.
Amol PatilUniversity of Nebraska Medical Center, Omaha, USA.
Sabin BistaUniversity of Nebraska Medical Center, Omaha, USA.
Daniel HershbergerUniversity of Nebraska Medical Center, Omaha, USA.
Brian BoerUniversity of Nebraska Medical Center, Omaha, USA.
University of Nebraska Medical Center · USUniversity College of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary tumor embolism (PTE) and pulmonary tumor thrombotic microangiopathy (PTTM) are rare etiologies for rapidly progressive dyspnea in the setting of undiagnosed metastatic cancer. They occur most frequently in association with adenocarcinomas, with PTE being most frequently associated with hepatocellular carcinoma and PTTM being most commonly reported with gastric adenocarcinoma. Pulmonary tumor embolism and PTTM appear to be a disease spectrum where PTTM represents an advanced form of PTE. Pulmonary tumor embolism and PTTM are mostly identified postmortem during autopsy as the antemortem diagnosis remains a clinical challenge due to the rapidly progressive nature of these rare diseases. We report 2 cases of rapidly progressive respiratory failure leading to death, due to tumoral pulmonary hypertension resulting from PTE and PTTM, diagnosed postmortem. Both of the patients were middle-aged females, nonsmokers, and had a gastrointestinal source of their primary malignancy.

Indexed as

AdenocarcinomaLung NeoplasmsNeoplastic Cells, CirculatingPulmonary EmbolismRespiratory InsufficiencyThrombotic MicroangiopathiesDyspneaFemaleHumansMiddle Agedautopsycor pulmonalemetastatic cancerPTEPTTMpulmonary tumor embolismpulmonary tumor thrombotic microangiopathyrespiratory failuretumoral pulmonary hypertension

Identifiers

PMID35313765
PMCPMC8943465
OpenAlexW4220721860

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.