Evidence map›Paper›PMID 35313697›Full record

ReviewiScience2022

Embedding digital chronotherapy into bioelectronic medicines.

John E Fleming, Vaclav Kremen, Ro'ee Gilron, Nicholas M Gregg, Mayela Zamora, Derk-Jan Dijk, Philip A Starr, Gregory A Worrell, Simon Little, Timothy J Denison

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  14. Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms.Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics · 2023
    Article
  15. Article
  16. An embedded intracranial seizure monitor for objective outcome measurements and rhythm identification.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023
    Article
  17. Article
  18. Regulation of arousal and performance of a healthy non-human primate using closed-loop central thalamic deep brain stimulation.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2023
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

John E FlemingMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Vaclav KremenBioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Ro'ee GilronDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Nicholas M GreggBioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Mayela ZamoraInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Derk-Jan DijkSurry Sleep Research Centre, University of Surrey, University of Surrey, Guildford, UK.
Philip A StarrDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Gregory A WorrellBioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Simon LittleDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Timothy J DenisonMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Mayo Clinic · USUniversity of California, San Francisco · USUniversity of Oxford · GBUniversity of Surrey · GB

Funding

Medical Research Council MC_UU_00003/3
6 · The paper itself

Abstract

Biological rhythms pervade physiology and pathophysiology across multiple timescales. Because of the limited sensing and algorithm capabilities of neuromodulation device technology to-date, insight into the influence of these rhythms on the efficacy of bioelectronic medicine has been infeasible. As the development of new devices begins to mitigate previous technology limitations, we propose that future devices should integrate chronobiological considerations in their control structures to maximize the benefits of neuromodulation therapy. We motivate this proposition with preliminary longitudinal data recorded from patients with Parkinson's disease and epilepsy during deep brain stimulation therapy, where periodic symptom biomarkers are synchronized to sub-daily, daily, and longer timescale rhythms. We suggest a physiological control structure for future bioelectronic devices that incorporates time-based adaptation of stimulation control, locked to patient-specific biological rhythms, as an adjunct to classical control methods and illustrate the concept with initial results from three of our recent case studies using chronotherapy-enabled prototypes.

Indexed as

BioelectronicsBiological sciencesBiotechnologyNeuroscience

Identifiers

PMID35313697
PMCPMC8933700
OpenAlexW4221064441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.