Evidence map›Paper›PMID 35313658›Full record

ArticleMolecular therapy. Nucleic acids2022

The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.

Guifang Du, Xiang Xu, Junting Wang, Xuejun Wang, Yang Ding, Fei Li, Yu Sun, Huan Tao, Yawen Luo, Hao Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Guifang DuInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Xiang XuInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Junting WangThe First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Xuejun WangInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Yang DingInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Fei LiComputer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.
Yu SunInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Huan TaoInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Yawen LuoInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Hao LiInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Xiaochen BoInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Hebing ChenInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Beijing Tsinghua Chang Gung Hospital · CNComputer Network Information Center · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past year, the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the worldwide coronavirus disease 2019 (COVID-19) pandemic. Yet our understanding of the SARS-CoV-2 tropism mechanism is still insufficient. In this study, we examined the chromatin accessibility at the promoters of host factor genes (

Indexed as

ACE2chromatin accessibilityhost factorsMT: BioinformaticsSARS-CoV-2TMPRSS2

Identifiers

PMID35313658
PMCPMC8925281
OpenAlexW4220887399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.