Evidence map›Paper›PMID 35313654›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2021

3D imaging of the vagus nerve fascicular anatomy with cryo-imaging and UV excitation.

Chaitanya Kolluru, Ananya Subramaniam, Yehe Liu, Aniruddha Upadhye, Monty Khela, Lindsey Druschel, Farzad Fereidouni, Richard Levenson, Andrew Shoffstall, Michael Jenkins and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chaitanya KolluruDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Ananya SubramaniamDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Yehe LiuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Aniruddha UpadhyeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Monty KhelaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Lindsey DruschelDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Farzad FereidouniDepartment of Pathology, Univ. of California Davis, CA USA.
Richard LevensonDepartment of Pathology, Univ. of California Davis, CA USA.
Andrew ShoffstallDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Michael JenkinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
David L WilsonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Case Western Reserve University · USUniversity of California, Davis · US

Funding

3D Microscopy with Ultraviolet Surface Excitation (3D-MUSE)R01EB028635 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI LEVENSON, RICHARD M., WILSON, DAVID LYNN · 2019 to 2023
$2.7M
NIBIB NIH HHS R01 EB028635
6 · The paper itself

Abstract

Vagus nerve stimulation (VNS) is a method to treat drug-resistant epilepsy and depression, but therapeutic outcomes are often not ideal. Newer electrode designs such as intra-fascicular electrodes offer potential improvements in reducing off-target effects but require a detailed understanding of the fascicular anatomy of the vagus nerve. We have adapted a section-and-image technique, cryo-imaging, with UV excitation to visualize fascicles along the length of the vagus nerve. In addition to offering optical sectioning at the surface via reduced penetration depth, UV illumination also produces sufficient contrast between fascicular structures and connective tissue. Here we demonstrate the utility of this approach in pilot experiments. We imaged fixed, cadaver vagus nerve samples, segmented fascicles, and demonstrated 3D tracking of fascicles. Such data can serve as input for computer models of vagus nerve stimulation.

Indexed as

cryo-imagingfasciclesnerve anatomyvagus nerve

Identifiers

PMID35313654
PMCPMC8934573
OpenAlexW3134962273

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.