Evidence map›Paper›PMID 35313527›Full record

ArticleOncoTargets and therapy2022

Progression-Free Survival of a Patient with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: A Case Report.

Guodai Hong, Silun Xie, Zikuan Guo, Diping Zhang, Sihai Ge, Suqin Zhang, Wenbin Gao

Open access · goldAbstract readCase Reports
In one paragraph

Article in OncoTargets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guodai HongDepartment of Oncology, The Third Affiliated Hospital of Shenzhen University (Shenzhen Luohu People's Hospital), Shenzhen, 518002, People's Republic of China.ORCID 0000-0002-2391-2462
Silun XieShenzhen Cell Biotechnology Co., Ltd, Shenzhen, 518054, People's Republic of China.ORCID 0000-0002-6057-7288
Zikuan GuoBeijing Clin- Biotechnology Co., Ltd, Beijing, 100070, People's Republic of China.
Diping ZhangShenzhen Cell Biotechnology Co., Ltd, Shenzhen, 518054, People's Republic of China.ORCID 0000-0001-9482-1114
Sihai GeShenzhen Cell Biotechnology Co., Ltd, Shenzhen, 518054, People's Republic of China.
Suqin ZhangDepartment of Oncology, The Third Affiliated Hospital of Shenzhen University (Shenzhen Luohu People's Hospital), Shenzhen, 518002, People's Republic of China.
Wenbin GaoDepartment of Oncology, The Third Affiliated Hospital of Shenzhen University (Shenzhen Luohu People's Hospital), Shenzhen, 518002, People's Republic of China.
Shenzhen University · CNBeijing VDJBio (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive cell therapy (ACT) is a promising treatment that is considered safe and efficient. Natural killer (NK) cells play an important role in the innate immune system and destroy target cells such as tumor cells without prior sensitization. Here, we report a 59-year-old man with advanced diffuse hepatocellular carcinoma (HCC) who underwent 17 courses of NK cell treatment from March 2017 to July 2018. Although he presented with progressive disease, his hydrothorax and ascites decreased, and his state of mind, appetite and quality of life were markedly improved after treatment versus at admission. To date, his survival time is >48 months. Here, we provide evidence that NK cell adoptive therapy has no adverse effects, enhances immune function, and improves the quality of life of patients with HCC.

Indexed as

hepatocellular carcinomanatural killer cell therapyprolonged survival

Identifiers

PMID35313527
PMCPMC8934175
OpenAlexW4220690844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.