Evidence map›Paper›PMID 35313355›Full record

ArticleCellular and molecular life sciences : CMLS2022

Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death.

Binnur Eroglu, Xiongjie Jin, Sadiki Deane, Bahadır Öztürk, Owen A Ross, Demetrius Moskophidis, Nahid F Mivechi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Binnur Eroglu *Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.
Xiongjie Jin *Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.
Sadiki DeaneMolecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.
Bahadır ÖztürkMolecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.
Owen A RossMayo Clinic, 4500 San Pablo Rd., Jacksonville, FL, 32224, USA.
Demetrius MoskophidisMolecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA. dmoskofidis@augusta.edu.
Nahid F MivechiMolecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA. nmivechi@augusta.edu.ORCID http://orcid.org/0000-0002-3510-9968
Augusta University · USMayo Clinic in Florida · USSelçuk University · TRUniversity of Utah · US

Funding

Role of heat shock transcription factor HSF1 in tumoroginesisR01CA062130 · NCI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MIVECHI, NAHID F, MOSKOFIDIS, DIMITRIOS · 1996 to 2025
$9.0M
Role of heat shock factors (Hsfs) in tumorigenesisR01CA132640 · NCI · AUGUSTA UNIVERSITY · PI MIVECHI, NAHID F · 2008 to 2018
$2.7M
BLRD VA I01 BX000161NCI NIH HHS CA062130NCI NIH HHS R01 CA062130NCI NIH HHS R01 CA132640
6 · The paper itself

Abstract

The dual specificity protein phosphatases (Dusps) control dephosphorylation of mitogen-activated protein kinases (MAPKs) as well as other substrates. Here, we report that Dusp26, which is highly expressed in neuroblastoma cells and primary neurons is targeted to the mitochondrial outer membrane via its NH

Indexed as

AnimalsCell DeathCell RespirationCells, CulturedCytoprotectionDopaminergic NeuronsDual-Specificity PhosphatasesHEK293 CellsHumansMaleMiceMice, 129 StrainMice, KnockoutMitochondriaMitogen-Activated Protein Kinase PhosphatasesNeurodegenerative DiseasesDual-Specificity PhosphatasesDUSP26 protein, humanMitogen-Activated Protein Kinase PhosphatasesDopaminergic neuronsDusp26LRRK2Mouse modelNeurodegenerationp38

Identifiers

PMID35313355
PMCPMC10601927
OpenAlexW4220989008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.