Evidence map›Paper›PMID 35313224›Full record

ArticleJournal of the neurological sciences2022

Inflammatory demyelinating polyneuropathy after the ChAdOx1 nCoV-19 vaccine may follow a chronic course.

Aaron de Souza, Wai M Oo, Pradeep Giri

Open access · greenAbstract read
In one paragraph

Article in Journal of the neurological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Case report of secondary T-cell deficiency following the AstraZeneca COVID-19 vaccine.The journal of allergy and clinical immunology. Global · 2024
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  11. Co-VAN study: COVID-19 vaccine associated neurological diseases- an experience from an apex neurosciences centre and review of the literature.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Aaron de SouzaDepartment of Medicine, Launceston General Hospital, 274-280 Charles Street, Launceston TAS 7250, Australia; Faculty of Medicine, Launceston Clinical School, University of Tasmania, Launceston TAS 7250, Australia. Electronic address: aaron.de.souza@ths.tas.gov.au.
Wai M OoDepartment of Medicine, Launceston General Hospital, 274-280 Charles Street, Launceston TAS 7250, Australia.
Pradeep GiriDepartment of Medicine, Launceston General Hospital, 274-280 Charles Street, Launceston TAS 7250, Australia.
Launceston General Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRare autoimmune neurological events have been reported during the ongoing global drive for mass vaccination as a means of controlling the Covid-19 pandemic. Guillain-Barré syndrome, an acute inflammatory neuropathy well recognised as a rare complication of influenza vaccination, has been reported to follow administration of the ChAdOx1 nCoV-19 (AstraZeneca) vaccine.

methodsWe report four patients with inflammatory demyelinating polyneuropathy after vaccination in whom a relapsing or progressive course indicated the development of chronic inflammatory demyelinating polyneuropathy (CIDP).

conclusionsAwareness of this complication and distinction from Guillain-Barré syndrome enables the timely institution of maintenance immunomodulatory treatment. Our report also highlights the likely relationship between vaccination and the subsequent development of CIDP, but definitive demonstration of a causal link needs larger studies.

Indexed as

COVID-19Graft vs Host DiseaseGuillain-Barre SyndromePolyradiculoneuropathy, Chronic Inflammatory DemyelinatingVaccinesChAdOx1 nCoV-19HumansPandemicsChAdOx1 nCoV-19VaccinesAstraZeneca vaccineCIDPCovid-19Guillain-Barré syndromeInflammatory demyelinating neuropathy

Identifiers

PMID35313224
PMCPMC8923716
OpenAlexW4220913370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.