Evidence map›Paper›PMID 35312985›Full record

ReviewHead and neck pathology2022

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.

Ozgur Mete, Bruce M Wenig

Open access · greenAbstract readReview
In one paragraph

Review in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 2 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Nodule size significantly affects the diagnostic value of chinese thyroid imaging reporting and data system: a multi-center retrospective study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  8. Neuroendocrine Carcinoma of the Head and Neck: A Two-Decade Institutional Experience.World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  9. Clinical-radiopathological features and EBV DNA dynamics in nasopharyngeal neuroendocrine carcinoma: implications for prognosis and surveillance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Ozgur MeteDepartment of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, Canada. ozgur.mete2@uhn.ca.ORCID http://orcid.org/0000-0003-0469-2801
Bruce M WenigDepartment of Pathology Moffitt Cancer Center, Tampa, FL, USA.
Moffitt Cancer Center · USUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review article provides a brief overview of the new WHO classification by adopting a question-answer model to highlight the spectrum of head and neck neuroendocrine neoplasms which includes epithelial neuroendocrine neoplasms (neuroendocrine tumors and neuroendocrine carcinomas) arising from upper aerodigestive tract and salivary glands, and special neuroendocrine neoplasms including middle ear neuroendocrine tumors (MeNET), ectopic or invasive pituitary neuroendocrine tumors (PitNET; formerly known as pituitary adenoma) and Merkel cell carcinoma as well as non-epithelial neuroendocrine neoplasms (paragangliomas). The new WHO classification follows the IARC/WHO nomenclature framework and restricts the diagnostic term of neuroendocrine carcinoma to poorly differentiated epithelial neuroendocrine neoplasms. In this classification, well-differentiated epithelial neuroendocrine neoplasms are termed as neuroendocrine tumors (NET), and are graded as G1 NET (no necrosis and < 2 mitoses per 2 mm

Indexed as

Carcinoma, NeuroendocrineHead and Neck NeoplasmsNeuroendocrine TumorsParagangliomaPituitary NeoplasmsHumansKi-67 AntigenWorld Health OrganizationKi-67 AntigenBiomarkersHead and neck neuroendocrine neoplasmsMerkel cell carcinomaNeuroendocrine carcinomaNeuroendocrine tumorsParagangliomaPituitary adenomaPituitary neuroendocrine tumorWHO classification

Identifiers

PMID35312985
PMCPMC9018952
OpenAlexW4220769815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.