ArticleHead and neck pathology2022
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Article in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 4 of them syntheses that pooled it.
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Who cites it
183 citing papers in PubMed, 4 syntheses or guidelines pooled it, 335 citations in OpenAlex.
- MicroRNAs in Salivary Gland Cancers Associated with Poor Prognosis: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Salivary Gland Oncocytomas. A Systematic Review.Head and neck pathology · 2024Pooled it
- DNA mismatch repair system expression in salivary gland tumors: A Systematic Review.Medicina oral, patologia oral y cirugia bucal · 2024Pooled it
- The prognostic significance of tertiary lymphoid structures in oral squamous cell carcinomas: a systematic review.Frontiers in oral health · 2024Pooled it
- A phase II trial of nivolumab for patients with platinum-refractory recurrent or metastatic salivary gland cancer.Japanese journal of clinical oncology · 2026Trial
- Hyalinizing Clear Cell Carcinoma of the Lung With Uncommon Distant Cutaneous Metastasis and Aggressive Clinical Course.Journal of cutaneous pathology · 2026Article
- Incidence and survival of epithelial salivary glands cancer by tumor site and histology in Tarragona and Girona, Catalonia, Spain.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Article
- Single-Nucleus Transcriptomes of Lacrimal Gland Adenoid Cystic Carcinoma With Different Growth Patterns.Head & neck · 2026Article
- [Update on salivary gland surgery].HNO · 2026Review
- Pathogenesis of Warthin's Tumors: A Critical Synthesis of the Evidence.Head and neck pathology · 2026Review
- Imaging of benign salivary gland tumors: an update based on the fifth WHO classification, with a focus on rare histologic types and newly listed entities-part I.Japanese journal of radiology · 2026Review
- Sialadenoma papilliferum of the floor of the mouth with HPV Positivity: a rare case report and literature review.Oral and maxillofacial surgery · 2026Review
- Keratocystoma of the Parotid Gland: A Systematic Review of Clinicopathologic Characteristics.Laryngoscope investigative otolaryngology · 2026Review
- Epidemiological Characterizations and Diagnostic Strategies Variation in Parotid Gland Tumors (2010-2024): Observations Based on 2133 Cases.Cancer medicine · 2026Article
- Imaging of benign salivary gland tumors under the fifth WHO classification, with a focus on rare histologic types and newly listed entities-Part II.Japanese journal of radiology · 2026Review
- Evaluation of Serum HIF-1α as a Hypoxia-Related Biomarker in Patients with Malignant Salivary Gland Neoplasms.Biomedicines · 2026Article
- Parotid mucoepidermoid carcinoma presenting as a cutaneous mass.JAAD case reports · 2026Article
- Extensive Bone Destruction, Lymphovascular and Perineural Invasion, and Local Recurrence: Unusual Features in Salivary Gland Microsecretory Adenocarcinoma.Head and neck pathology · 2026Article
- Tissue Homogenate VEGF Levels in Malignant Salivary Gland Tumors vs. Controls: An Exploratory Pilot Study.Journal of clinical medicine · 2026Article
123 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The salivary gland section in the 5th edition of the World Health Organization Classification of Head and Neck Tumours features a description and inclusion of several new entities, including sclerosing polycystic adenoma, keratocystoma, intercalated duct adenoma, and striated duct adenoma among the benign neoplasms; and microsecretory adenocarcinoma and sclerosing microcystic adenocarcinoma as the new malignant entities. The new entry also includes mucinous adenocarcinoma subdivided into papillary, colloid, signet ring, and mixed subtypes with recurrent AKT1 E17K mutations across patterns suggesting that mucin-producing salivary adenocarcinomas represent a histologically diverse single entity that may be related to salivary intraductal papillary mucinous neoplasm (IPMN). Importantly, the number of entities in the salivary chapter has been reduced by omitting tumors or lesions if they do not occur exclusively or predominantly in salivary glands, including hemangioma, lipoma, nodular fasciitis and hematolymphoid tumors. They are now discussed in detail elsewhere in the book. Cribriform adenocarcinoma of salivary gland origin (CASG) now represents a distinctive subtype of polymorphous adenocarcinoma (PAC). PAC is defined as a clinically, histologically and molecularly heterogeneous disease group. Whether CASG is a different diagnostic category or a variant of PAC is still controversial. Poorly differentiated carcinomas and oncocytic carcinomas are discussed in the category "Salivary carcinoma not otherwise specified (NOS) and emerging entities". New defining genomic alterations have been characterized in many salivary gland tumors. In particular, they include gene fusions, which have shown to be tightly tumor-type specific, and thus valuable for use in diagnostically challenging cases. The recurrent molecular alterations were included in the definition of mucoepidermoid carcinoma, adenoid cystic carcinoma, secretory carcinoma, polymorphous adenocarcinoma, hyalinizing clear cell carcinoma, mucinous adenocarcinoma, and microsecretory adenocarcinoma.
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