ReviewHead and neck pathology2022
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Review in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Lymphoepithelial carcinoma of the esophagus with primary squamous cell carcinoma of the hypopharynx: complete response was achieved by chemoradiation therapy.Clinical journal of gastroenterology · 2026Article
- Immunohistochemical characterization of the tumor immune microenvironment in laryngeal premalignancy: insights into early immune alterations in carcinogenesis.Virchows Archiv : an international journal of pathology · 2026Article
- Phonosurgical Treatment of Laryngeal Leukoplakia and Dysplasia: Results of Multidimensional Voice Diagnostics Including the VEM.Diagnostics (Basel, Switzerland) · 2026Article
- Biomarkers for Predicting Malignant Transformation of Premalignant Lesions of the Larynx: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Management of Vocal Fold Leukoplakia.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Article
- Moderate Laryngeal Dysplasia in the Context of Classification Systems and Clinical Decision Making.The Laryngoscope · 2025Article
- Assessing the Accuracy, Safety, and Tolerance of Office-Based Endoscopic Biopsies for Laryngopharyngeal Lesions.The Laryngoscope · 2025Article
- [Overall survival, organ preservation, function preservation: the role of surgery in the treatment of laryngeal cancer].Magyar onkologia · 2025Review
- Tracheal squamous cell carcinoma treated with tracheal resection and anastomosis in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Insights on Bmi-1 therapeutic targeting in head and neck cancers.Oncology research · 2025Review
- Head and neck myofibroma: A case series of 16 cases and literature review.Medicina oral, patologia oral y cirugia bucal · 2024Review
- Significance of P53-Binding Protein 1 as a Novel Molecular Histological Marker for Hypopharyngeal Squamous Neoplasms.Cancers · 2024Article
- The sensitivity of laryngeal findings in predicting high-grade dysplasia in patients with vocal fold leukoplakia undergoing office-based biopsies: A retrospective analysis of 100 cases.Laryngoscope investigative otolaryngology · 2024Article
- Is precision medicine the solution to improve organ preservation in laryngeal/hypopharyngeal cancer? A position paper by the Preserve Research Group.Frontiers in oncology · 2024Review
- Clinical significance of type IV vascularization of laryngeal lesions according to the Ni classification.Frontiers in oncology · 2024Article
- Revealing molecular and cellular heterogeneity in hypopharyngeal carcinogenesis through single-cell RNA and TCR/BCR sequencing.Frontiers in immunology · 2024Article
- Next-Generation Sequencing Analysis of Mutations in Circulating Tumor DNA from the Plasma of Patients with Head-Neck Cancer Undergoing Chemo-Radiotherapy Using a Pan-Cancer Cell-Free Assay.Current oncology (Toronto, Ont.) · 2023Article
- The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous Cell Carcinomas of the Larynx.Medicina (Kaunas, Lithuania) · 2023Article
- Neuroendocrine Neoplasms of the Head and Neck: A Case Report on an Oropharyngeal Presentation.Cureus · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this article, we review the chapter on tumors of the larynx, hypopharynx, trachea and parapharyngeal space in the new edition of the WHO book, focusing on the new developments in comparison to the previous edition. Squamous cell carcinoma (SCC) and its variants are by far the most common malignancies at these locations, with very limited new insights. The most important is the introduction of new targeted treatment-checkpoint inhibitors, with a new task for pathologists, who may help to predict the response to treatment by analyzing the expression of targeted proteins in biopsy samples. Precancerous lesions remain a controversial topic and, similarly to other organs, it is acceptable to use the terms "dysplasia" or "squamous intraepithelial lesion" (SIL), but there is a slight difference between low-grade dysplasia and low-grade SIL: in the former, mild atypia must be present, while the latter also includes hyperplastic epithelium without atypia. Two approaches have been proposed: a two-tiered system with low- and high-grade dysplasia/SIL and a three-tiered system with an additional category, carcinoma in situ. We are still searching for reliable diagnostic markers to surpass the subjectivity in biopsy diagnosis, with a few potential candidate markers on the horizon, e.g., stem cell markers. Other tumors are rare at these locations, e.g., hematolymphoid, neuroendocrine and salivary gland neoplasms, and are no longer included in Chapter 3. They must be diagnosed according to criteria described in specific chapters. The same holds true for soft tissue tumors, with the exception of cartilaginous neoplasms, which are still included in Chapter 3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.