ArticleEuropean journal of epidemiology2022
Generalizability and effect measure modification in sibling comparison studies.
Article in European journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Peripubertal pregnancies and associations with health and developmental outcomes in offspring during late adolescence and adulthood: sibling-comparison register study.International journal of epidemiology · 2026Article
- Serum IL-6 and IL-10 in Early Childhood Caries: A Sibling-Controlled Study in Children Aged 2.5-6 Years.Diagnostics (Basel, Switzerland) · 2026Article
- Cardiorespiratory fitness in adolescence and premature mortality: widespread bias identified using negative control outcomes and sibling comparisons.European journal of preventive cardiology · 2026Article
- Genetically Informed Research Designs in Perinatal Pharmacoepidemiology: A Methodological Overview.Drug safety · 2026Review
- Bidirectional Association Between Premenstrual Disorders and Psychiatric Disorders.JAMA network open · 2026Article
- Hypertensive disorders of pregnancy, maternal cardiovascular disease mortality and the role of familial predisposition: a Norwegian population-based sibling-comparison, sibling-spillover and negative-control cohort study.American journal of epidemiology · 2026Article
- Moving beyond risk ratios in sibling analysis: estimating clinically useful measures from family-based analysis.European journal of epidemiology · 2026Article
- First trimester antidepressant use and miscarriage: a population-based cohort study using Clinical Practice Research Datalink GOLD.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Overstated association between adolescent physical fitness and adulthood depression risk due to familial factors.Journal of internal medicine · 2025Article
- Adolescent cardiorespiratory fitness and risk of cancer in late adulthood: A nationwide sibling-controlled cohort study in Sweden.PLoS medicine · 2025Article
- Associations of maternal blood biomarkers of prenatal APAP exposure with placental gene expression and child attention deficit hyperactivity disorder.Nature. Mental health · 2025Article
- Cardiorespiratory fitness in adolescence and risk of type 2 diabetes in late adulthood in one million Swedish men: nationwide sibling controlled cohort study.BMJ medicine · 2025Article
- Stress-Related Disorders Among Young Individuals With Surgical Removal of Tonsils or Adenoids.JAMA network open · 2024Article
- Cardiorespiratory Fitness in Adolescence and Risk of Type 2 Diabetes in Late Adulthood: A Nationwide Sibling-Controlled Cohort Study.medRxiv : the preprint server for health sciences · 2024Article
- Maternal early pregnancy body mass index and risk of sleep apnea in the offspring.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Impact of traumatic brain injury on risk for schizophrenia and bipolar disorder.Psychiatry research · 2024Article
- The bidirectional association between premenstrual disorders and perinatal depression: A nationwide register-based study from Sweden.PLoS medicine · 2024Article
- Bidirectional association between autoimmune disease and perinatal depression: a nationwide study with sibling comparison.Molecular psychiatry · 2024Article
- Genetic and Environmental Factors and Cardiovascular Disease Risk in Adolescents.JAMA network open · 2023Article
- Association between cumulative psychosocial adversity in the family and ADHD and autism: a family-based cohort study.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Sibling comparison studies have the attractive feature of being able to control for unmeasured confounding by factors that are shared within families. However, there is sometimes a concern that these studies may have poor generalizability (external validity) due to the implicit restriction to families that are covariate-discordant, i.e., those families where at least two siblings have different levels of at least one of the covariates (exposure or confounders) under investigation. Even if this selection mechanism has been noted by many authors, previous accounts of the problem tend to be brief. The purpose of this paper is to provide a formal discussion of the implicit restriction to covariate-discordant families in sibling comparison studies. We discuss when and how this restriction may impair the generalizability of the study, and we show that a similar generalizability problem may in fact arise even when all families are covariate-discordant, e.g. even if the exposure is continuous so that all siblings have different exposure levels. We show how this problem can be solved by using a so-called marginal between-within model for estimation of marginal exposure effects. Finally, we illustrate the theoretical conclusions with a simulation study.
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