Evidence map›Paper›PMID 35312875›Full record

ArticleNano convergence2022

Antibody-conjugated gold nanoparticles as nanotransducers for second near-infrared photo-stimulation of neurons in rats.

Jiansheng Liu, Jiajia Li, Shu Zhang, Mengbin Ding, Ningyue Yu, Jingchao Li, Xiuhui Wang, Zhaohui Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano convergence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  5. Gold Nanorod-Embedded PDMS Micro-Pillar Array for Localized Photothermal Stimulation.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jiansheng Liu *Department of Neurology, Zhuhai People's Hospital, Zhuhai Hospital of Jinan University, Zhuhai, Guangdong, 519000, People's Republic of China.
Jiajia Li *Department of Neurology, Shanghai Eighth People's Hospital, Shanghai, 200233, People's Republic of China.
Shu Zhang *Department of Neurology, Zhuhai People's Hospital, Zhuhai Hospital of Jinan University, Zhuhai, Guangdong, 519000, People's Republic of China.
Mengbin DingShanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People's Republic of China.
Ningyue YuShanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People's Republic of China.
Jingchao LiShanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People's Republic of China. jcli@dhu.edu.cn.ORCID http://orcid.org/0000-0002-8994-3202
Xiuhui WangInstitute of Translational Medicine, Shanghai University, Shanghai, 200011, People's Republic of China. blackrabbit@shu.edu.cn.
Zhaohui LiDepartment of Neurology, Zhuhai People's Hospital, Zhuhai Hospital of Jinan University, Zhuhai, Guangdong, 519000, People's Republic of China. Lzh6207@126.com.
Donghua University · CNJinan University · CNShanghai University · CN

Funding

Fundamental Research Funds for the Central Universities 2232021A-05Postdoctoral Research Foundation of China 2021M703790Science and Technology Commission of Shanghai Municipality 20DZ2254900
6 · The paper itself

Abstract

Infrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive neural modulation modality. Optical nanoparticles with the absorption in the near-infrared (NIR) window have emerged as excellent photothermal transducers due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency and limited stimulation depth are main predicaments encountered in the neural stimulation mediated by these nanoparticles. In this study, we prepared a targeted polydopamine (PDA)-coated gold (Au) nanoparticles with specific binding to thermo-sensitive ion channel as nanotransducers for second near-infrared (NIR-II) photo-stimulation of neurons in rats. The targeted Au nanoparticles were constructed via conjugation of anti-TRPV1 antibody with PEGylated PDA-coated Au nanoparticles and thus exhibited potent photothermal performance property in the second NIR (NIR-II) window and converted NIR-II light to heat to rapidly activate Ca

Indexed as

Gold nanoparticlesNear-infraredNeural stimulationPhotothermal transducersPolydopamine

Identifiers

PMID35312875
PMCPMC8938552
OpenAlexW4220857784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.