Evidence map›Paper›PMID 35312415›Full record

ArticleGrowth factors (Chur, Switzerland)

Quantile-specific heritability of serum growth factor concentrations.

Paul T Williams

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Growth factors (Chur, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Paul T WilliamsLawrence Berkeley National Laboratory, Molecular Biophysics & Integrated Bioimaging Division, Berkeley, CA, USA.ORCID 0000-0002-4872-4556
Lawrence Berkeley National Laboratory · US

Funding

Gene-environment interaction vs quantile-dependent penetrance of established SNPsR21ES020700 · NIEHS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WILLIAMS, PAUL T · 2012 to 2014
$560k
NIEHS NIH HHS R21 ES020700
6 · The paper itself

Abstract

background"Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. growth factor concentration) is high or low relative to its distribution.

methodsQuantile-regression analysis was applied to family sets from the Framingham Heart Study to determine whether the heritability (

resultsQuantile-specific

conclusionHeritabilities of VEGF, HGF, angiopoitein-2, sTie-2 and sFlt-1 concentrations are quantile dependent. This may explain reported interactions of genetic loci (rs10738760, rs9472159, rs833061, rs3025039, rs2280789, rs1570360, rs2010963) with metabolic syndrome, diet, recurrent miscarriage, hepatocellular carcinoma, erysipelas, diabetic retinopathy, and bevacizumab treatment in their effect on VEGF concentrations.

Indexed as

Angiopoietin-2Vascular Endothelial Growth Factor APhenotypeVascular Endothelial Growth Factor Receptor-1Angiopoietin-2Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1angiopoietin-2angiopoietin-2 (Tie-2) receptorGene–environment interactionhepatocyte growth factorheritabilityprecision medicinevascular endothelial growth factorVEGFR1 (Flt-1) receptor

Identifiers

PMID35312415
PMCPMC10101221
OpenAlexW4221108217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.