ArticleDepression and anxiety2022
Reduced cortical volume of the default mode network in adolescents with generalized anxiety disorder.
Article in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Alterations in Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents.Brain and behavior · 2025Article
- Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder.BMC psychiatry · 2025Article
- Pre-pandemic mental health and brain characteristics predict adolescent stress and emotions during the COVID-19 pandemic.PloS one · 2025Article
- Structural brain alterations in patients with anxious depression: evidence from the REST-meta-MDD project.Frontiers in psychiatry · 2025Article
- Smaller hippocampal volume is associated with anxiety symptoms in high-risk Black youth.Journal of mood and anxiety disorders · 2024Article
- A Shared Multivariate Brain-Behavior Relationship in a Transdiagnostic Sample of Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Altered functional connectivity of the default mode network in non-arteritic anterior ischaemic optic neuropathy.Brain communications · 2024Article
- Lysergic Acid Diethylamide (LSD) for the Treatment of Anxiety Disorders: Preclinical and Clinical Evidence.CNS drugs · 2023Review
- Identification of structural brain alterations in adolescents with depressive symptomatology.Brain research bulletin · 2023Article
- Reduced cortical volume of the default mode network in adolescents with generalized anxiety disorder.Depression and anxiety · 2022Article
- Abnormal hubs in global network as potential neuroimaging marker in generalized anxiety disorder at rest.Frontiers in psychology · 2022Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWidespread structural alterations have been shown to be implicated in individuals with generalized anxiety disorder (GAD). However, there have been inconsistent findings in cortical volume (CV) differences. Most structural neuroimaging studies looking at GAD used region-based approach with relatively small sample sizes, let alone be specific to adolescents with GAD. We believe this is the first study to look at CV measures using a network-based approach in a larger sample of adolescents with GAD. The goal of the current study was to focus on three different brain networks (i.e., Limbic, Frontoparietal, and Default Mode Network [DMN]) in adolescents with GAD.
methodThe study involved 81 adolescents with GAD and 112 typically developing (TD) comparison individuals matched on age (15.98 and 15.63 respective means), sex (42F/39M and 45F/67M), and IQ (101.90 and 103.94 respective means). Participants underwent structural MRI. Freesurfer was used to estimate CV (both network-specific and region-specific within networks) and region-specific sub-cortical volume measures. Multivariate analysis of covariance (MANCOVA; with sex, age, IQ, and intracranial volume [ICV] as potential covariates) was used to estimate group differences.
resultsWe found significantly lower CV for the DMN in adolescents with GAD, compared with TD individuals. Adolescents with GAD also showed significantly lower hemispheric mean CV of the default-mode regions (particularly the prefrontal and temporal regions) and the hippocampus, compared with TD individuals.
conclusionThe current findings suggest structural alterations in adolescents with GAD. These structural alterations will need to be addressed when implementing and developing treatments for patients with GAD.
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