Evidence map›Paper›PMID 35312111›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2022

A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia.

Anna Sadnicka, Lorenzo Rocchi, Anna Latorre, Elena Antelmi, James Teo, Isabel Pareés, Britt S Hoffland, Kristian Brock, Katja Kornysheva, Mark J Edwards and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. The blink reflex and its modulation - Part 1: Physiological mechanisms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  4. Article
  5. Neurophysiology of cerebellar ataxias and gait disorders.Clinical neurophysiology practice · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Anna SadnickaDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-6132-2773
Lorenzo RocchiDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Anna LatorreDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-7103-5209
Elena AntelmiDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0003-1739-6139
James TeoDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Isabel PareésDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Britt S HofflandDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Kristian BrockCancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Katja KornyshevaSchool of Psychology, University of Birmingham, Birmingham, UK.
Mark J EdwardsDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Kailash P BhatiaDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-8185-286X
John C RothwellDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0003-1367-6467
University College London · GBSt George's, University of London · GBCancer Research UK Clinical Trials Unit · GBHospital Ruber Internacional · ESKing's College Hospital NHS Foundation Trust · GBRadboud University Nijmegen · NLUniversity of Birmingham · GBUniversity of Cagliari · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired eyeblink conditioning is often cited as evidence for cerebellar dysfunction in isolated dystonia yet the results from individual studies are conflicting and underpowered.

objectiveTo systematically examine the influence of dystonia, dystonia subtype, and clinical features over eyeblink conditioning within a statistical model which controlled for the covariates age and sex.

methodsOriginal neurophysiological data from all published studies (until 2019) were shared and compared to an age- and sex-matched control group. Two raters blinded to participant identity rescored all recordings (6732 trials). After higher inter-rater agreement was confirmed, mean conditioning per block across raters was entered into a mixed repetitive measures model.

resultsIsolated dystonia (P = 0.517) and the subtypes of isolated dystonia (cervical dystonia, DYT-TOR1A, DYT-THAP1, and focal hand dystonia) had similar levels of eyeblink conditioning relative to controls. The presence of tremor did not significantly influence levels of eyeblink conditioning. A large range of eyeblink conditioning behavior was seen in both health and dystonia and sample size estimates are provided for future studies.

conclusionsThe similarity of eyeblink conditioning behavior in dystonia and controls is against a global cerebellar learning deficit in isolated dystonia. Precise mechanisms for how the cerebellum interplays mechanistically with other key neuroanatomical nodes within the dystonic network remains an open research question. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.

Indexed as

Dystonic DisordersTorticollisApoptosis Regulatory ProteinsBlinkingCerebellumConditioning, ClassicalDNA-Binding ProteinsHumansMolecular ChaperonesApoptosis Regulatory ProteinsDNA-Binding ProteinsMolecular ChaperonesTHAP1 protein, humanTOR1A protein, humanassociative learningcerebellumdystoniaeyeblink conditioning

Identifiers

PMID35312111
PMCPMC9313805
OpenAlexW4220724997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.