Evidence map›Paper›PMID 35311713›Full record

ArticleJournal of Parkinson's disease2022

Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.

Donald L Bliwise, Elias G Karroum, Sophia A Greer, Stewart A Factor, Lynn Marie Trotti

Open access · greenAbstract read
In one paragraph

Article in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Polysomnographic features of idiopathic restless legs syndrome: a systematic review and meta-analysis of 13 sleep parameters and 23 leg movement parameters.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Pooled it
  2. Review
  3. Unraveling sleep dysfunction in progressive supranuclear palsy: a pilot study on the role of periodic limb movements in sleep and insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Donald L BliwiseDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Elias G KarroumDepartment of Neurology, George Washington University School of Medicine, Washington, DC, USA.
Sophia A GreerSchool of Medicine, University of Missouri, Columbia, MO, USA.
Stewart A FactorDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Lynn Marie TrottiDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · USGeorge Washington University · USUniversity of Missouri · US

Funding

Antibiotic-mediated improvements in vigilance: mechanisms of action of clarithromycin in hypersomnia syndromesR01NS111280 · NINDS · EMORY UNIVERSITY · PI TROTTI, LYNN MARIE · 2019 to 2023
$2.2M
Emory Clinical Research Site for NEXTU10NS077366 · NINDS · EMORY UNIVERSITY · PI FACTOR, STEWART A · 2011 to 2017
$1.8M
Sleep/Wake Contiuum in Lewy Body DiseaseR01NS050595 · NINDS · EMORY UNIVERSITY · PI BLIWISE, DONALD L. · 2006 to 2010
$1.7M
Sleepiness and sleep drunkenness: narcolepsy versus GABA-related hypersomniaK23NS083748 · NINDS · EMORY UNIVERSITY · PI TROTTI, LYNN MARIE · 2014 to 2018
$918k
NINDS NIH HHS K23 NS083748NINDS NIH HHS R01 NS050595NINDS NIH HHS R01 NS111280NINDS NIH HHS U10 NS077366
6 · The paper itself

Abstract

backgroundThe association between restless legs syndrome (RLS) and Parkinson's disease (PD) remains controversial, with epidemiologic and descriptive evidence suggesting some potential overlap while mechanistic/genetic studies suggesting relative independence of the conditions.

objectiveTo examine a known, objectively measured endophenotype for RLS, periodic leg movements (PLMS) in sleep, in patients with PD and relate that objective finding to restless legs symptoms.

methodsWe performed polysomnography for one (n = 8) or two (n = 67) consecutive nights in 75 PD patients and examined the association of PLMS with restless legs symptoms.

resultsWe found no association between restless legs symptoms and PLMS in PD. Prevalence of both was similar to data reported previously in other PD samples.

conclusionWe interpret these results as suggesting that restless legs symptoms in PD patients may represent a different phenomenon and pathophysiology than RLS in the non-PD population.

Indexed as

Nocturnal Myoclonus SyndromeParkinson DiseaseRestless Legs SyndromeHumansLegSleepParkinson’s diseaseperiodic leg movements in sleepRestless legs

Identifiers

PMID35311713
PMCPMC9156558
OpenAlexW4220822178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.