ArticleInfection control and hospital epidemiology2023
Prolonged silent carriage, genomic virulence potential and transmission between staff and patients characterize a neonatal intensive care unit (NICU) outbreak of methicillin-resistant
Article in Infection control and hospital epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Evolution of Antimicrobial Resistance in Neonatal Sepsis: A Narrative Review.Antibiotics (Basel, Switzerland) · 2026Review
- Investigation and control of a meticillin-resistantInfection prevention in practice · 2026Article
- Whole-genome sequencing reveals a unique outbreak of methicillin-resistantInfection prevention in practice · 2026Article
- Rapid dissemination of Staphylococcus aureus in the neonatal intensive care unit is associated with invasive infection.Nature communications · 2026Article
- Implementation and outcomes of a rapid response genomic hospital epidemiology programme at an academic medical centre over 7 years.The Lancet. Microbe · 2026Review
- Article
- Antibiotic Resistance, Biofilm Formation, and Molecular Epidemiology of FoodborneFood science & nutrition · 2025Article
- Tracking Antimicrobial Resistant Organisms Timely: a workflow validation study for successive core-genome SNP-based nosocomial transmission analysis.JAC-antimicrobial resistance · 2025Article
- Rapid identification and subsequent contextualization of an outbreak of methicillin-resistantMicrobial genomics · 2024Article
- Antibiotic resistance, biofilm formation, and molecular epidemiology of Staphylococcus aureus in a tertiary hospital in Xiangyang, China.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Article
- Linking preterm infant gut microbiota to nasograstric enteral feeding tubes: exploring potential interactions and microbial strain transmission.Frontiers in pediatrics · 2024Article
- Environmental Persistence of Staphylococcus capitis NRCS-A in Neonatal Intensive Care Units: Role of Biofilm Formation, Desiccation, and Disinfectant Tolerance.Microbiology spectrum · 2022Article
- Genetic Diversity, Antibiotic Resistance, and Virulence Gene Features of Methicillin-ResistantInfection and drug resistance · 2022Article
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMethicillin-resistant
objectiveImproving our understanding of MRSA transmission dynamics, especially among high-risk patients, is an infection prevention priority.
methodsWe investigated a cluster of clinical MRSA cases in the NICU using a combination of epidemiologic review and whole-genome sequencing (WGS) of isolates from clinical and surveillance cultures obtained from patients and healthcare personnel (HCP).
resultsPhylogenetic analysis identified 2 genetically distinct phylogenetic clades and revealed multiple silent-transmission events between HCP and infants. The predominant outbreak strain harbored multiple virulence factors. Epidemiologic investigation and genomic analysis identified a HCP colonized with the dominant MRSA outbreak strain who cared for most NICU patients who were infected or colonized with the same strain, including 1 NICU patient with severe infection 7 months before the described outbreak. These results guided implementation of infection prevention interventions that prevented further transmission events.
conclusionsSilent transmission of MRSA between HCP and NICU patients likely contributed to a NICU outbreak involving a virulent MRSA strain. WGS enabled data-driven decision making to inform implementation of infection control policies that mitigated the outbreak. Prospective WGS coupled with epidemiologic analysis can be used to detect transmission events and prompt early implementation of control strategies.
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