Evidence map›Paper›PMID 35311580›Full record

ArticleInfection and immunity2022

Preclinical Immunogenicity and Efficacy of Optimized O25b O-Antigen Glycoconjugates To Prevent MDR ST131 E. coli Infections.

Laurent Chorro, Zhenghui Li, Ling Chu, Suddham Singh, Jianxin Gu, Jin-Hwan Kim, Kaushik Dutta, Rosalind Pan, Srinivas Kodali, Duston Ndreu and 14 more

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Loss of O-antigen due toScience advances · 2026
    Article
  2. Article
  3. Review
  4. Review
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  6. Article
  7. A cynomolgus monkeyInfection and immunity · 2024
    Article
  8. Preclinical validation of anMicrobiology spectrum · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Laurent ChorroPfizer Vaccine Research and Development, Pearl River, New York, USA.
Zhenghui LiPfizer Vaccine Research and Development, Pearl River, New York, USA.
Ling ChuPfizer Vaccine Research and Development, Pearl River, New York, USA.
Suddham SinghPfizer Vaccine Research and Development, Pearl River, New York, USA.
Jianxin GuPfizer Vaccine Research and Development, Pearl River, New York, USA.
Jin-Hwan KimPfizer Vaccine Research and Development, Pearl River, New York, USA.
Kaushik DuttaPfizer Vaccine Research and Development, Pearl River, New York, USA.
Rosalind PanPfizer Vaccine Research and Development, Pearl River, New York, USA.
Srinivas KodaliPfizer Vaccine Research and Development, Pearl River, New York, USA.
Duston NdreuPfizer Vaccine Research and Development, Pearl River, New York, USA.
Axay PatelPfizer Vaccine Research and Development, Pearl River, New York, USA.
Julio C HawkinsPfizer Vaccine Research and Development, Pearl River, New York, USA.
Chris PoncePfizer Vaccine Research and Development, Pearl River, New York, USA.
Natalie Silmon de MonerriPfizer Vaccine Research and Development, Pearl River, New York, USA.
David KeeneyPfizer Vaccine Research and Development, Pearl River, New York, USA.
Arthur IllenbergerPfizer Vaccine Research and Development, Pearl River, New York, USA.
C Hal JonesPfizer Vaccine Research and Development, Pearl River, New York, USA.
Lubomira AndrewPfizer Vaccine Research and Development, Pearl River, New York, USA.
Jason LotvinPfizer Vaccine Research and Development, Pearl River, New York, USA.
A Krishna PrasadPfizer Vaccine Research and Development, Pearl River, New York, USA.
Isis KanevskyPfizer Vaccine Research and Development, Pearl River, New York, USA.
Kathrin U JansenPfizer Vaccine Research and Development, Pearl River, New York, USA.
Annaliesa S AndersonPfizer Vaccine Research and Development, Pearl River, New York, USA.
Robert G K DonaldPfizer Vaccine Research and Development, Pearl River, New York, USA.ORCID 0000-0002-1002-954X
Pfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multivalent O-antigen polysaccharide glycoconjugate vaccines are under development to prevent invasive infections caused by pathogenic

Indexed as

Escherichia coli InfectionsO AntigensAnimalsCarrier ProteinsEscherichia coliGlycoconjugatesMiceCarrier ProteinsGlycoconjugatesO AntigensEscherichia coliglycoconjugate vaccineMDRO25bO antigenST131

Identifiers

PMID35311580
PMCPMC9022517
OpenAlexW4220714485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.