ArticleBone & joint research2022
Do preoperative intra-articular injections of corticosteroids or hyaluronic acid increase the risk of infection after total knee arthroplasty? A meta-analysis.
Article in Bone & joint research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Preoperative intra-articular steroid injections within 3 months increase the risk of periprosthetic joint infection in total knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Revision sacroiliac joint fusion: mid-term patient-reported outcomes.Journal of spine surgery (Hong Kong) · 2026Article
- Relationship Between Intraarticular Injections on Patient-reported Outcomes in Total Knee Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Impact of intra-articular injection on infection risk and therapeutic effect after unicompartmental knee arthroplasty: a retrospective cohort study.Archives of orthopaedic and trauma surgery · 2025Article
- Review
- Risk of Periprosthetic Joint Infection after Intra-Articular Injection: Any Difference among Shoulder, Knee and Hip?Healthcare (Basel, Switzerland) · 2024Review
- Preoperative Risk Factors for Periprosthetic Joint Infection: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- Intra-articular corticosteroid injections for osteoarthritis: A qualitative study of patients' and clinicians' experiences.PloS one · 2024Article
- Management of Greater Trochanteric Pain Syndrome After Total Hip Arthroplasty: Practice Patterns and Surgeon Attitudes.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2023Article
- Tips and tricks in ultrasound-guided musculoskeletal interventional procedures.Journal of ultrasonography · 2023Article
- Pre-operative corticosteroid injection within 1 month of total shoulder arthroplasty is associated with increased risk of periprosthetic joint infection.Archives of orthopaedic and trauma surgery · 2023Article
- Total Knee Arthroplasty in Unrecognized Septic Arthritis-A Descriptive Case Series Study.Antibiotics (Basel, Switzerland) · 2023Article
- Review
- Risk Factors for Periprosthetic Joint Infection after Primary Total Knee Arthroplasty.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThere is conflicting evidence on the safety of intra-articular injections of hyaluronic acid (HA) or corticosteroids (CSs) before total knee arthroplasty (TKA). We performed a meta-analysis of the relationship between intra-articular injections and subsequent infection rates after TKA.
methodsWe searched PubMed, EMBASE, and the Cochrane Library for cohort studies that assessed the effect of preoperative injection of drugs into the joint cavity on the infection rate after TKA. The outcomes analyzed included the total infection rate, as well as those for different preoperative injection time periods and different drugs.
resultsEight studies, including 73,880 in the injection group and 126,187 in the control group, met the inclusion criteria. The injection group had a significantly higher postoperative infection rate than the control group (risk ratio (RR) 1.16; 95% confidence interval (CI) 1.07 to 1.27; p < 0.001; I
conclusionCurrent evidence suggests that intra-articular injections of CSs or HA before TKA increase the risk of postoperative infection. Injections administered more than three months before TKA do not significantly increase the risk of infection. Cite this article:
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Registered trials
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