Evidence map›Paper›PMID 35311553›Full record

ArticleMicrobiology spectrum2022

Comparison of Isogenic Strains Shows No Evidence of Altered Nosocomial Transmission-Competency of Rough, GPL-Negative Mycobacterium abscessus Strains.

Michal Meir, Mark Foreman, Michal Bar-Oz, Noga Naor, Anna Rozenblit, Daniel Barkan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michal MeirThe Ruth Rappaport Children's Hospital, Rambam Medical Center, Haifa, Israel.
Mark ForemanKoret School of Veterinary Medicine, The Robert H. Smith Faculty for Agriculture, The Hebrew University of Jerusalemgrid.9619.7, Rehovot, Israel.
Michal Bar-OzKoret School of Veterinary Medicine, The Robert H. Smith Faculty for Agriculture, The Hebrew University of Jerusalemgrid.9619.7, Rehovot, Israel.
Noga NaorKoret School of Veterinary Medicine, The Robert H. Smith Faculty for Agriculture, The Hebrew University of Jerusalemgrid.9619.7, Rehovot, Israel.
Anna RozenblitKoret School of Veterinary Medicine, The Robert H. Smith Faculty for Agriculture, The Hebrew University of Jerusalemgrid.9619.7, Rehovot, Israel.
Daniel BarkanKoret School of Veterinary Medicine, The Robert H. Smith Faculty for Agriculture, The Hebrew University of Jerusalemgrid.9619.7, Rehovot, Israel.ORCID 0000-0002-5691-1757
Hebrew University of Jerusalem · IL

Funding

The roles of sRNA in the physiology and pathogenesis of Mycobacterium abscessus and other mycobacteriaR21AI156415 · NIAID · WORCESTER POLYTECHNIC INSTITUTE · PI SHELL, SCARLET SARA · 2021 to 2022
$395k
NIAID NIH HHS R21 AI156415
6 · The paper itself

Abstract

Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections. While environmental in origin, in the clinical setting M. abscessus often changes to a Rough phenotype associated with severe non-remitting infections. Clinical isolates baring mutations in glycopeptidolipid-synthesis genes, leading to the Rough phenotype, were suggested to have increase bacterial virulence while possibly showing reduced transmissibility on fomites. We set to determine whether an isolated glycopeptidolipid (GPL) defect affects transmissibility. We used transposon technology to create a fully isogenic Rough (GPL-defective) (Tn_4099c) and compare it to the isogenic parent strain (ATCC 19977). Survival on fomites was determined by spotting, drying, and retrieving the isolates at designated time points. This was repeated as a competition experiment using a mixture of differentially fluorescent M. abscessus

Indexed as

Cross InfectionDisinfectantsMycobacterium abscessusMycobacterium Infections, NontuberculousChlorhexidineHumansChlorhexidineDisinfectantsinfection controlMycobacterium abscessustransmissionvirulence

Identifiers

PMID35311553
PMCPMC9045370
OpenAlexW4220889265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.