Evidence map›Paper›PMID 35311458›Full record

ArticleGut microbes

Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study.

Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle V Ward, Randall Pellish and 4 more

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Trial
  4. Review
  5. Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  8. Association rule mining of the human gut microbiome.Science China. Life sciences · 2026
    Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Barbara OlendzkiDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0003-4307-5187
Vanni BucciDepartment of Microbiology and Physiological Systems and Program of Microbiome Dynamics. University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-3257-2922
Caitlin CawleyDepartment of Microbiology and Physiological Systems and Program of Microbiome Dynamics. University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Rene MaseratiDepartment of Microbiology and Physiological Systems and Program of Microbiome Dynamics. University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Margaret McManusCenter for Clinical and Translational Science, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Effie OlednzkiCenter for Applied Nutrition, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Camilla MadziarDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
David ChiangDepartment of Medicine,University of Massachusetts Medical School Worcester, Massachusetts, USA.
Doyle V WardDepartment of Microbiology and Physiological Systems and Program of Microbiome Dynamics. University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-4952-824X
Randall PellishUMass Memorial Medical Center University Campus, Department of Gastroenterology.
Christine FoleyDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Shakti BhattaraiDepartment of Microbiology and Physiological Systems and Program of Microbiome Dynamics. University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Beth A McCormickDepartment of Microbiology and Physiological Systems and Program of Microbiome Dynamics. University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0001-5992-2673
Ana Maldonado-ContrerasDepartment of Microbiology and Physiological Systems and Program of Microbiome Dynamics. University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-5967-9623

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome "imbalance" or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of

Indexed as

Gastrointestinal MicrobiomeInflammatory Bowel DiseasesDietDysbiosisHumansPilot ProjectsPrebioticsPrebioticsdietdysbiosisIBDMicrobiome

Identifiers

PMID35311458
PMCPMC8942410

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.