ArticleGut microbes
Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain's reward center.
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Impacts of Lifestyle and Microbiota-Targeted Interventions for Overweight and Obesity on the Human Gut Microbiome: A Systematic Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Fecal microbiota transplantation in obesity: a comprehensive overview from basic research to clinical application.Frontiers in microbiology · 2026Pooled it
- The Involvement of Serotonin in the Obesity Pathway-A Last Decade Systematic Review of the Literature.International journal of molecular sciences · 2025Pooled it
- A systematic review exploring the association between the human gut microbiota and brain connectivity in health and disease.Molecular psychiatry · 2023Pooled it
- Trial
- Inulin supplementation modulates gut microbiota derived metabolites related to brain function in children with obesity.Scientific reports · 2025Trial
- Gut microbiota and blood biomarkers as correlating factors in patients with postoperative delirium: analysis of three prospective observational studies.Molecular psychiatry · 2026Article
- A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.Brain, behavior, & immunity - health · 2026Article
- Does sex moderate health and Alzheimer's disease risk tied to early educational experiences? The reducing inequities through social and educational change follow-up in early adulthood extension study protocol.Brain, behavior, & immunity - health · 2026Article
- Associations of Adiposity With Gut Microbiota Composition Among Adults-Results From a Federated Analysis of Individual Participant Data From Eight European Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
- Gut microbiome shift in long COVID: impact of disease and montelukast treatment.Journal of global health · 2026Article
- Effects of a brown rice-derived supplement on physical, cognitive and mental health among adults and the role of the gut microbiota: study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial.BMC complementary medicine and therapies · 2026Article
- Exploring the gut microbiota alterations with obesity in older adults: a case-control study in the context of Bushehr Elderly Health (BEH) program.Journal of health, population, and nutrition · 2026Article
- Integrated safety and microbiota profiling of fulvic acid formulations across in vitro and in vivo models.Scientific reports · 2026Article
- Functional divergence of the gut microbiome associated with lifestyle and helminth infection in Indigenous Peninsular Malaysian.Research square · 2026Article
- Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults.Gut microbes reports · 2026Article
- Identifying gut microbiota composition disparities in autistic individuals and their unaffected siblings: correlations with clinical characteristics.Translational psychiatry · 2025Article
- Fructose catabolism and its metabolic effects: Exploring host-microbiota interactions and the impact of ethnicity.The Journal of physiology · 2025Review
- Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences.Biology of sex differences · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The prevalence of obesity has risen to its highest values over the last two decades. While many studies have either shown brain or microbiome connections to obesity, few have attempted to analyze the brain-gut-microbiome relationship in a large cohort adjusting for cofounders. Therefore, we aim to explore the connection of the brain-gut-microbiome axis to obesity controlling for such cofounders as sex, race, and diet. Whole brain resting state functional MRI was acquired, and connectivity and brain network properties were calculated. Fecal samples were obtained from 287 obese and non-obese participants (males n = 99, females n = 198) for 16s rRNA profiling and fecal metabolites, along with a validated dietary questionnaire. Obesity was associated with alterations in the brain's reward network (nucleus accumbens, brainstem). Microbial diversity (p = .03) and composition (p = .03) differed by obesity independent of sex, race, or diet. Obesity was associated with an increase in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.