ArticleThe Journal of urology2022
Fragmentation of Stones by Burst Wave Lithotripsy in the First 19 Humans.
Article in The Journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study of the SonoMotion Break Wave(TM) System for the Comminution of Urinary Tract Stones
Ultrasound Technology to Fragment and Reposition Urinary Stones
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Randomized Controlled Trial of Ultrasonic Propulsion-Facilitated Clearance of Residual Kidney Stone Fragments vs Observation.The Journal of urology · 2024Trial
- Break Wave Lithotripsy for Urolithiasis: Results of the First-in-Human International Multi-Institutional Clinical Trial.The Journal of urology · 2024Trial
- Removal of Small, Asymptomatic Kidney Stones and Incidence of Relapse.The New England journal of medicine · 2022Trial
- Improving Burst Wave Lithotripsy Effectiveness for Small Stones and Fragments by Increasing Frequency: Theoretical Modeling andJournal of endourology · 2022Trial
- Sound therapy in renal disease management: a narrative review by the Kasr Al-Ainy Nephrology Group (KANG).International urology and nephrology · 2026Review
- Burst wave lithotripsy for the treatment of obstructive ureteroliths in cats.Journal of veterinary internal medicine · 2026Article
- No Injury Observed in Kidneys Treated with Burst Wave Lithotripsy in Therapeutically Anticoagulated Pigs.Journal of endourology · 2025Article
- Facilitated Clearance of Small, Asymptomatic Renal Stones With Burst Wave Lithotripsy and Ultrasonic Propulsion.The Journal of urology · 2025Article
- Fracture and Fragmentation of Vascular Calcifications by Focused Ultrasound.Journal of cardiovascular translational research · 2025Article
- Burst wave lithotripsy - a paradigm shift: inferences from a scoping review.World journal of urology · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- 2D spatiotemporal passive cavitation imaging and evaluation during ultrasound thrombolysis based on diagnostic ultrasound platform.Ultrasonics sonochemistry · 2024Article
- Revealing physical interactions of ultrasound waves with the body through photoelasticity imaging.Optics and lasers in engineering · 2024Article
- Article
- Development of a burst wave lithotripsy system for noninvasive fragmentation of ureteroliths in pet cats.BMC veterinary research · 2023Article
- Application of ultrasound imaging in the treatment of urinary tract stones.Journal of medical ultrasonics (2001) · 2023Review
- High-frequency shock wave lithotripsy: stone comminution and evaluation of renal parenchyma injury in a porcine ex-vivo model.World journal of urology · 2023Article
- Article
- Functional and Morphological Changes Associated with Burst Wave Lithotripsy-Treated Pig Kidneys.Journal of endourology · 2022Article
- First Series Using Ultrasonic Propulsion and Burst Wave Lithotripsy to Treat Ureteral Stones.The Journal of urology · 2022Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
purposeWe report stone comminution in the first 19 human subjects by burst wave lithotripsy (BWL), which is the transcutaneous application of focused, cyclic ultrasound pulses. MATERIALS AND
methodsThis was a prospective multi-institutional feasibility study recruiting subjects undergoing clinical ureteroscopy (URS) for at least 1 stone ≤12 mm as measured on computerized tomography. During the planned URS, either before or after ureteroscope insertion, BWL was administered with a handheld transducer, and any stone fragmentation and tissue injury were observed. Up to 3 stones per subject were targeted, each for a maximum of 10 minutes. The primary effectiveness outcome was the volume percent comminution of the stone into fragments ≤2 mm. The primary safety outcome was the independent, blinded visual scoring of tissue injury from the URS video.
resultsOverall, median stone comminution was 90% (IQR 20, 100) of stone volume with 21 of 23 (91%) stones fragmented. Complete fragmentation (all fragments ≤2 mm) within 10 minutes of BWL occurred in 9 of 23 stones (39%). Of the 6 least comminuted stones, likely causative factors for decreased effectiveness included stones that were larger than the BWL beamwidth, smaller than the BWL wavelength or the introduction of air bubbles from the ureteroscope. Mild reddening of the papilla and hematuria emanating from the papilla were observed ureteroscopically.
conclusionsThe first study of BWL in human subjects resulted in a median of 90% comminution of the total stone volume into fragments ≤2 mm within 10 minutes of BWL exposure with only mild tissue injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.