Evidence map›Paper›PMID 35311271›Full record

ArticleOrganic letters2022

Oxetan-3-ols as 1,2-bis-Electrophiles in a Brønsted-Acid-Catalyzed Synthesis of 1,4-Dioxanes.

Juan J Rojas, Elena Torrisi, Maryne A J Dubois, Riashat Hossain, Andrew J P White, Giovanni Zappia, James J Mousseau, Chulho Choi, James A Bull

Abstract read
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Oxetanes in Drug Discovery Campaigns.Journal of medicinal chemistry · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan J RojasDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, U.K.ORCID 0000-0002-9471-5888
Elena TorrisiDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, U.K.
Maryne A J DuboisDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, U.K.
Riashat HossainDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, U.K.
Andrew J P WhiteDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, U.K.
Giovanni ZappiaDepartment of Biomolecular Sciences, School of Pharmacy, University of Urbino "Carlo Bo", P.za Rinascimento, 6, 61029 Urbino (PU), Italy.
James J MousseauPfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States.
Chulho ChoiPfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States.ORCID 0000-0003-3459-3767
James A BullDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, U.K.ORCID 0000-0003-3993-5818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Annulations that combine diacceptors with bis-nucleophiles are uncommon. Here, we report the synthesis of 1,4-dioxanes from 3-aryloxetan-3-ols, as 1,2-bis-electrophiles and 1,2-diols. Brønsted acid Tf

Indexed as

AlcoholsDioxanesCatalysisStereoisomerism1,4-dioxaneAlcoholsDioxanes

Identifiers

PMID35311271
PMCPMC9007565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.