Evidence map›Paper›PMID 35311080›Full record

ArticleFrontiers in oncology2022

B7H6 Serves as a Negative Prognostic Marker and an Immune Modulator in Human Pancreatic Cancer.

Zheng Zhu, Kun-Yu Teng, Jian Zhou, Yunyun Xu, Lifeng Zhang, Hua Zhao, Xueguang Zhang, Lei Tian, Zhiyao Li, Ting Lu and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 6 institutions in 2 countries.

Zheng ZhuDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Kun-Yu TengDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Jian ZhouDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yunyun XuPediatric Clinical Research Institute, Children's Hospital Affiliated to Soochow University, Suzhou, China.
Lifeng ZhangDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Hua ZhaoDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xueguang ZhangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Lei TianDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Zhiyao LiDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Ting LuDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Shoubao MaDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Zhenlong LiDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Zhenyu DaiDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Jing WangDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Xingyu ChenDepartment of General Surgery, Taizhou Fourth People's Hospital, Taizhou, China.
Xing WuDepartment of General Surgery, The First People's Hospital of Huzhou, Huzhou, China.
Yihan PanCollege of Liberal Arts, University of Minnesota Twin Cities, Minneapolis, MN, United States.
Weiqiang ShiDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhiqun YouDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Hanyu ChenDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Vincent ChungDepartment of Medical Oncology, City of Hope National Medical Center, Los Angeles, CA, United States.
Jianhua YuDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States.
Songbing HeDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xin ZhaoDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Lei CaoJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Dechun LiDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
City Of Hope National Medical Center · USFirst Affiliated Hospital of Soochow University · CNSoochow University · CNTaizhou Fourth People's Hospital · CNThird People's Hospital of Huzhou · CNUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer (PC), the third leading cause of cancer-related death in the U.S., is frequently found too late to be cured by traditional chemotherapy. Expression of B7 homolog 6 (B7H6), a member of the B7 family of immunoreceptors, has been found in PC and several other cancers. B7H6 is a ligand for cytotoxicity triggering receptor 3 (NKp30), which is expressed on NK cells. Here, we demonstrate that B7H6 can be detected in PC tissues but not normal organs. Its expression in patients associated significantly with tumor differentiation grade and lymphatic metastasis. The soluble form of B7H6 was detected in the PC patients' sera, and its concentration associated with tumor differentiation grade and tumor, node, metastasis (TNM) stages. Also, higher levels of B7H6 in PC patients' malignant tissues or serum correlated with shorter overall survival.

Indexed as

B7 homolog 6 (B7H6)NK cellsNKp30pancreatic cancer (PC)prognosis

Identifiers

PMID35311080
PMCPMC8929685
OpenAlexW4214884515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.