Evidence map›Paper›PMID 35311021›Full record

ArticleACS pharmacology & translational science2022

Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators.

Yan-Ling Zhang, Sean P Moran, Andrew Allen, David Baez-Nieto, Qihong Xu, Lei A Wang, William E Martenis, Joshua R Sacher, Jennifer P Gale, Michel Weïwer and 2 more

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yan-Ling ZhangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Sean P MoranStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.ORCID https://orcid.org/0000-0001-7672-242X
Andrew AllenStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
David Baez-NietoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Qihong XuStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Lei A WangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
William E MartenisStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Joshua R SacherStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Jennifer P GaleStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Michel WeïwerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.ORCID https://orcid.org/0000-0002-4897-1450
Florence F WagnerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Jen Q PanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Broad Institute · US

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1M
Experience-Dependent Reorganization of Excitatory Synapse ConnectivityR01MH118298 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAN, JEN QIAN, POPESCU, GABRIELA K · 2019 to 2023
$3.3M
High-Throughput Screens for CaV3.3 Selective T-type Calcium Channel ModulatorsR01MH115045 · NIMH · BROAD INSTITUTE, INC. · PI COTTRELL, JEFFREY RICHARD, PAN, JEN QIAN · 2018 to 2020
$2.3M
Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep SpindleR01MH131719 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN, WEÏWER, MICHEL · 2022 to 2023
$1.8M
NIMH NIH HHS R01 MH115045NIMH NIH HHS R01 MH118298NIMH NIH HHS R01 MH131719NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

T-type voltage-gated Ca

Identifiers

PMID35311021
PMCPMC8923061
OpenAlexW4214518857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.