Evidence map›Paper›PMID 35310934›Full record

ArticleAnalytical cellular pathology (Amsterdam)2022

miR-590-5p Overexpression Alleviates

Lin Shang, Tao Peng, Xuemei Chen, Zhiyong Yan, Junmin Wang, Xiaoqun Gao, Cheng Chang

Open access · goldAbstract read
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lin ShangDepartment of Human Anatomy, School of Basic Medicine, Zhengzhou University, China.ORCID https://orcid.org/0000-0001-6281-6214
Tao PengDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, China.ORCID https://orcid.org/0000-0001-9807-6174
Xuemei ChenDepartment of Human Anatomy, School of Basic Medicine, Zhengzhou University, China.ORCID https://orcid.org/0000-0001-5614-6859
Zhiyong YanDepartment of Human Anatomy, School of Basic Medicine, Zhengzhou University, China.ORCID https://orcid.org/0000-0002-3057-3323
Junmin WangDepartment of Human Anatomy, School of Basic Medicine, Zhengzhou University, China.ORCID https://orcid.org/0000-0001-9830-0164
Xiaoqun GaoDepartment of Human Anatomy, School of Basic Medicine, Zhengzhou University, China.ORCID https://orcid.org/0000-0002-8665-0674
Cheng ChangDepartment of Human Anatomy, School of Basic Medicine, Zhengzhou University, China.ORCID https://orcid.org/0000-0002-1387-911X
Zhengzhou University · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is one common degenerative disorder. However, the effects of miR-590-5p on AD and the mechanism on modulation of AD development were unclear. In this study, the miR-590-5p level in AD patients at mild, moderate, and severe stage as well as APP/PS1 transgenic mice was detected by qRT-PCR. The relationship of miR-590-5p and pellino-1 (PELI1) was identified by double luciferase reporter gene assay. Afterwards, both BV-2 and HT22 cells were exposed to

Indexed as

Amyloid beta-PeptidesMicroRNAsNuclear ProteinsUbiquitin-Protein LigasesAnimalsApoptosisCell ProliferationHumansMiceNeuronsAmyloid beta-PeptidesMicroRNAsMIRN590 microRNA, humanNuclear ProteinsPELI1 protein, humanPeli1 protein, mouseUbiquitin-Protein Ligases

Identifiers

PMID35310934
PMCPMC8924595
OpenAlexW4220676822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.