ArticleInternational journal of physiology, pathophysiology and pharmacology2022
Evaluation of the serum level of osteoprotegerin and bone mineral density in postmenopausal women.
Article in International journal of physiology, pathophysiology and pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Potential Biological and Genetic Links Between Dementia and Osteoporosis: A Scoping Review.Geriatrics (Basel, Switzerland) · 2025Review
- Picroside II regulates the YY1/TGFβ1 axis by inhibiting osteoblast ferroptosis to alleviate symptoms of postmenopausal osteoporosis.Cytotechnology · 2025Article
- OPG and TNFR1 as Potential Biomarkers of Inflammation in Older Adults with Acute COVID-19 and Indicators of Frailty in Post-COVID-19: A Pilot Study.Journal of inflammation research · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWomen might face different issues after menopause. Reduction in bone mineral density (BMD) is one of these problems that put a heavy burden on the healthcare system, especially in developing countries. Studies assume that along with increased age, lack of physical activity and hormonal issues, some other factors might take part in this process. Osteoprotegerin (OPG) is one of the assumed factors. Here we aimed to assess the relation between serum levels of OPG and BMD in postmenopausal women.
methodsIn this prospective cross-sectional study, 90 postmenopausal women were entered. Our cases were divided based on former medical documents into two groups of osteoporotic women (n=45) and healthy women (n=45). All cases were then analyzed using Dual-energy X-ray absorptiometry (DXA) and BMD and T-score were assessed for each case in different sites. Serum levels of OPG were also assessed using Enzyme-linked immunosorbent assay (ELISA). Data were then analyzed using SPSS software.
resultsThere were higher OPG levels in osteoporotic women compared with healthy women (P<0.001). We also indicated a significant difference in BMD between two groups of postmenopausal women in different sites (i.e. lumbar vertebrae L2-L4, trochanters, femoral neck and hip). We showed there is a reverse relation between serum OPG levels and BMD in lumbar vertebrae (r=-0.4, P=0.002), hip (r=-0.3, P=0.03) and femoral neck (r=-0.3, P=0.02) in both groups. There is a reverse relation between BMD and serum levels of OPG in postmenopausal women.
conclusionOPG levels are higher in osteoporotic women and have a reverse relation with BMD.
Indexed as
Identifiers
35310860PMC8918604W4226064867What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.