Evidence map›Paper›PMID 35310856›Full record

ArticleFrontiers in cellular and infection microbiology2022

Greater Phage Genotypic Diversity Constrains Arms-Race Coevolution.

Meaghan Castledine, Pawel Sierocinski, Mhairi Inglis, Suzanne Kay, Alex Hayward, Angus Buckling, Daniel Padfield

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Hawaiian Geothermal Fumaroles Contain Diverse and Novel Viruses.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. The Zoetrope effect in phage evolution.Frontiers in microbiology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Harnessing phages to tackle antimicrobial resistance: a Saudi Arabian perspective.Frontiers in cellular and infection microbiology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Meaghan CastledineCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Cornwall, United Kingdom.
Pawel SierocinskiCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Cornwall, United Kingdom.
Mhairi InglisCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Cornwall, United Kingdom.
Suzanne KayCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Cornwall, United Kingdom.
Alex HaywardCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Cornwall, United Kingdom.
Angus BucklingCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Cornwall, United Kingdom.
Daniel PadfieldCollege of Life and Environmental Sciences, Environment and Sustainability Institute, University of Exeter, Cornwall, United Kingdom.
University of Exeter · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N020146/1Medical Research Council MR/N0137941/1
6 · The paper itself

Abstract

Antagonistic coevolution between hosts and parasites, the reciprocal evolution of host resistance and parasite infectivity, has important implications in ecology and evolution. The dynamics of coevolution-notably whether host or parasite has an evolutionary advantage-is greatly affected by the relative amount of genetic variation in host resistance and parasite infectivity traits. While studies have manipulated genetic diversity during coevolution, such as by increasing mutation rates, it is unclear how starting genetic diversity affects host-parasite coevolution. Here, we (co)evolved the bacterium

Indexed as

BacteriophagesPseudomonas fluorescensPseudomonas PhagesBiological EvolutionGenotypeHost-Parasite Interactionsarms racebacteriophagecoevolutionexperimental evolutiongenetic diversityinfectivityPseudomonas fluorescensresistance

Identifiers

PMID35310856
PMCPMC8931298
OpenAlexW4214863223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.