Evidence map›Paper›PMID 35310840›Full record

ReviewFrontiers in cellular and infection microbiology2022

Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase.

Chao Wang, Arne Krüger, Xiaochen Du, Carsten Wrenger, Matthew R Groves

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Single-cell analysis ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Genetic analysis of pyrimidine biosynthetic enzymes inbioRxiv : the preprint server for biology · 2025
    Article
  4. Revisiting theNPJ drug discovery · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chao WangDepartment of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Arne KrügerUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Xiaochen DuDepartment of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Carsten WrengerUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Matthew R GrovesDepartment of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
University of Groningen · NLUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria remains one of the most prominent and dangerous tropical diseases. While artemisinin and analogs have been used as first-line drugs for the past decades, due to the high mutational rate and rapid adaptation to the environment of the parasite, it remains urgent to develop new antimalarials. The pyrimidine biosynthesis pathway plays an important role in cell growth and proliferation. Unlike human host cells, the malarial parasite lacks a functional pyrimidine salvage pathway, meaning that RNA and DNA synthesis is highly dependent on the

Indexed as

AntimalarialsAspartate CarbamoyltransferaseAspartic AcidCrystallography, X-RayDrug DiscoveryPlasmodium falciparumProtozoan ProteinsAntimalarialsAspartate CarbamoyltransferaseAspartic AcidProtozoan Proteinsallosteric pocketanti-malarialsaspartate transcarbamoylasePlasmodium falciparumpyrimidine biosynthesisX-ray structure

Identifiers

PMID35310840
PMCPMC8931299
OpenAlexW4214943959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.