Evidence map›Paper›PMID 35310606›Full record

ArticleJournal of immunology research2022

Determination of T Cell Responses in Thai Systemic Sclerosis Patients.

Oranit Likhit, Worawit Louthrenoo, Sa-Nga Pattanakitsakul, Aroonroong Suttitheptumrong, Supot Hannongbua, Thanyada Rungrotmongkol, Hiroshi Noguchi, Fujio Takeuchi, Kobporn Boonnak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Evolving role of CD8Frontiers in immunology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Oranit LikhitDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Worawit LouthrenooDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 50200, Thailand.
Sa-Nga PattanakitsakulDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Aroonroong SuttitheptumrongDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Supot HannongbuaThe Center of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Thanyada RungrotmongkolBiocatalyst and Environmental Biotechnology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Hiroshi NoguchiSchool of Pharmacy, Nihon Pharmaceutical University, Saitama 361-0806, Japan.
Fujio TakeuchiSchool of Pharmaceutical Science, University of Shizuoka, Shizuoka 422-8526, Japan.
Kobporn BoonnakDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.ORCID https://orcid.org/0000-0002-7536-8964
Siriraj Hospital · THChulalongkorn University · THUniversity of Shizuoka · JPChiang Mai University · THMahidol University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study is aimed at determining the role of T cells by assessing the numbers of IFN- Methods: Fifty Thai SSc patients and 50 healthy controls (HC) joined this study. IFN- Results: In SSc patients, we detected a significantly higher number of IFN- Conclusion: The results from this study emphasize the critical role of DNA topoisomerase-I peptides on the activation of T cells in SSc patients. The findings provide a better understanding of SSc's immunopathogenesis and may lead to the development of diagnostic tools and specific treatments for SSc in the future.

Indexed as

CD8-Positive T-LymphocytesScleroderma, SystemicAntibodies, AntinuclearHumansInterferon-gammaThailandAntibodies, Antinuclearanti-scl-70 autoantibodiesInterferon-gamma

Identifiers

PMID35310606
PMCPMC8924789
OpenAlexW4221108410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.