ReviewAlzheimer's & dementia (New York, N. Y.)2022
Risk of conversion from mild cognitive impairment to dementia in low- and middle-income countries: A systematic review and meta-analysis.
Review in Alzheimer's & dementia (New York, N. Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Electroacupuncture Targeting the NLRP3 Inflammasome in Senescence‑associated Cognitive Impairment: Mechanistic Synthesis and Meta‑analysis of Clinical Randomized Controlled Trials.Neurochemical research · 2026Pooled it
- Motor Learning in Older Adults with Mild Cognitive Impairment: A Systematic Review.Neuropsychology review · 2026Pooled it
- Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies.Frontiers in public health · 2026Pooled it
- Social cognition in mild cognitive impairment and dementia: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Effects of aerobic exercise on cognitive function in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Effects of aerobic exercise interventions on cognitive function, sleep quality, and quality of life in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- The impact of social isolation from COVID-19-related public health measures on cognitive function and mental health among older adults: A systematic review and meta-analysis.Ageing research reviews · 2023Pooled it
- Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies.Journal of the American Geriatrics Society · 2022Pooled it
- Alzheimer's disease-like brain pattern biomarker: capturing risks and predicting disease onset.Molecular psychiatry · 2026Article
- The Cog-Aging: a 15-year cohort study of cognition in Brazilian older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Olfactory impairment associated with cognitive decline: findings from cognitive domain assessments among older adults in West Jakarta, Indonesia.BMC geriatrics · 2026Article
- Nonpharmacological multicomponent intervention for mild cognitive impairment with a family-patient approach: protocol for the pilot clinical trial-INTERCOG study.Pilot and feasibility studies · 2026Article
- Multidomain prediction of education-stratified MoCA-defined mild cognitive impairment in community-dwelling older adults in urban China.BMC geriatrics · 2026Article
- Characterizing olfaction, anxiety, and depression in subjective cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Interpretable machine learning for cognitive impairment assessment: integration of clinical and radiomic white matter hyperintensities features.Journal of translational medicine · 2026Article
- Semi-Supervised Clustering for Identification of MCI and Dementia Cohorts with a Brief Digital Cognitive Assessment.Research square · 2026Article
- Mechanisms of action and advances in application of music therapy in improving cognitive impairment based on the theory of neuroplasticity.Frontiers in neuroscience · 2026Review
- The association of mood disorders and mild cognitive impairment with language performance in older adults: insights from a community healthcare setting.Frontiers in dementia · 2026Article
- Dual-task, single challenge: functionality as an early marker of cognitive decline.Dementia & neuropsychologia · 2026Article
- The predictive power of neuropsychological measures in MCI: early detection of dementia conversion.Frontiers in aging neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: With no treatment for dementia, there is a need to identify high risk cases to focus preventive strategies, particularly in low- and middle-income countries (LMICs) where the burden of dementia is greatest. We evaluated the risk of conversion from mild cognitive ompairment (MCI) to dementia in LMICs. Methods: Medline, Embase, PsycINFO, and Scopus were searched from inception until June 30, 2020. The search was restricted to observational studies, conducted in population-based samples, with at least 1 year follow-up. There was no restriction on the definition of MCI used as long as it was clearly defined. PROSPERO registration: CRD42019130958. Results: Ten thousand six hundred forty-seven articles were screened; Conclusions: MCI is associated with high, but variable, conversion to dementia in LMICs and may be influenced by demographic and health factors. There is a notable absence of data from low-income settings and countries outside of China. This highlights the urgent need for research investment into aging and dementia in LMIC settings. Being able to identify those individuals with cognitive impairment who are at highest risk of dementia in LMICs is necessary for the development of risk reduction strategies that are contextualized to these unique settings.
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