ArticleNature aging2021
Intermittent and periodic fasting, longevity and disease.
Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06074861 (The Effect of a Fast-mimicking Diet on Periodontal Clinical and Systemic Response to Non-surgical Treatment of Stage III-IV Periodontitis), which is not on this map. Cited by 161 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of a Fast-mimicking Diet on Periodontal Clinical and Systemic Response to Non-surgical Treatment of Stage III-IV Periodontitis: a Multi-centre Randomised Controlled Trial With Internal Pilot
Who cites it
161 citing papers in PubMed, 3 syntheses or guidelines pooled it, 255 citations in OpenAlex.
- Relationship between Aging and Ketogenic Diet: A Bibliometric Analysis (1995-2025)Endocrine, metabolic & immune disorders drug targets · 2026Pooled it
- Could dietary restrictions affect periodontal disease? A systematic review.Clinical oral investigations · 2023Pooled it
- Therapeutic Fasting in Reducing Chemotherapy Side Effects in Cancer Patients: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects.GeroScience · 2026Trial
- Exploring the Immunomodulatory Effects of Fasting-Mimicking Diet in Healthy Individuals: A Pilot Study.Nutrients · 2026Trial
- A Fasting-Mimicking Diet Affects the Inflammatory Response Following Periodontal Treatment: A Multi-centre Feasibility Randomised Controlled Pilot Trial.Journal of clinical periodontology · 2026Trial
- The effect of 6-day fasting on physical performance and neuromuscular control in healthy men.Scientific reports · 2026Trial
- Health benefits of a five-day at-home modified fasting program: a randomised controlled trial.Genome medicine · 2026Trial
- Stable cognitive performance while adapting to intermittent fasting: A randomised controlled trial.Journal of health psychology · 2026Trial
- Sex-related differences in fine motor skills and muscle strength control during short-term fasting.Scientific reports · 2026Trial
- Trial
- Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.Nature aging · 2023Trial
- Innate immune remodeling by short-term intensive fasting.Aging cell · 2021Trial
- Trial
- A Hepatocyte-to-Stellate Cell Axis Couples Alternate-Day Fasting to Liver Fibrosis Resolution via ATG7 S-Nitrosylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nuclear class 3 PI3K co-activates fasting-specific chromatin remodelling.Nature cell biology · 2026Article
- AMPK Therapy-A Little Goes A Long Way.Cells · 2026Review
- Phosphorylation of OTUB1 promotes autophagy initiation under starvation.Nature communications · 2026Article
- A simplified intermittent fasting regimen robustly extendsbioRxiv : the preprint server for biology · 2026Article
- Intermittent fasting rewires tissue-specific gene-transposable element regulatory networks.PNAS nexus · 2026Article
101 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to affect longevity and healthspan by acting on cellular aging and disease risk factors, while causing no or minor side effects. IF lasting from 12 to 48 hours and repeated every 1 to 7 days and PF lasting 2 to 7 days and repeated once per month or less have the potential to prevent and treat disease, but their effect on cellular aging and the molecular mechanisms involved are only beginning to be unraveled. Here, we describe the different fasting methods and their effect on longevity in organisms ranging from yeast to humans, linking them to the major nutrient-sensing signaling pathways and focusing on the benefits of the fasting and the refeeding periods. We also discuss both the therapeutic potential and side effects of IF and PF with a focus on cancer, autoimmunity, neurodegeneration and metabolic and cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.