ArticleBioactive materials2022
Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants.
Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
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- Multifunctional ions/drugs co-delivering nanocomposite hydrogel orchestrates neuro-osteogenic microenvironment for boosting osteoporotic osseointegration.Journal of nanobiotechnology · 2026Article
- Long-term postoperative treatment of open fractures usingRSC advances · 2025Article
- Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration.Materials today. Bio · 2025Review
- Chirality-Induced Hydroxyapatite Manipulates Enantioselective Bone-Implant Interactions Toward Ameliorative Osteoporotic Osseointegration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advances in Functionalized Nanoparticles for Osteoporosis Treatment.International journal of nanomedicine · 2025Review
- Harnessing hydrogen sulfide in injectable hydrogels that guide the immune response and osteoclastogenesis balance for osteoporosis treatment.Materials today. Bio · 2024Article
- Strategies for Improving Impaired Osseointegration in Compromised Animal Models.Journal of dental research · 2024Review
- Biomedical applications of stimuli-responsive "smart" interpenetrating polymer network hydrogels.Materials today. Bio · 2024Review
- Electrospun fiber-based immune engineering in regenerative medicine.Smart medicine · 2024Review
- Functional adhesive hydrogels for biological interfaces.Smart medicine · 2023Review
- An injectable and self-healing hydrogel with dual physical crosslinking for in-situ bone formation.Materials today. Bio · 2023Article
- Hydrogel-based delivery system applied in the local anti-osteoporotic bone defects.Frontiers in bioengineering and biotechnology · 2022Review
- Hotspots and trends in stem cell therapy for ligament injuries: A bibliometric analysis (2001-2025).Cell transplantationReview
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effective osteointegration of orthopedic implants is a key factor for the success of orthopedic surgery. However, local metabolic imbalance around implants under osteoporosis condition could jeopardize the fixation effect. Inspired by the bone structure and the composition around implants under osteoporosis condition, alendronate (A) was grafted onto methacryloyl hyaluronic acid (H) by activating the carboxyl group of methacryloyl hyaluronic acid to be bonded to inorganic calcium phosphate on trabecular bone, which is then integrated with aminated bioactive glass (AB) modified by oxidized dextran (O) for further adhesion to organic collagen on the trabecular bone. The hybrid hydrogel could be solidified on cancellous bone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.