Evidence map›Paper›PMID 35310358›Full record

ReviewBioactive materials2022

Cells and material-based strategies for regenerative endodontics.

Zain Siddiqui, Amanda M Acevedo-Jake, Alexandra Griffith, Nurten Kadincesme, Kinga Dabek, Dana Hindi, Ka Kyung Kim, Yoshifumi Kobayashi, Emi Shimizu, Vivek Kumar

Abstract readReview
In one paragraph

Review in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zain SiddiquiDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Amanda M Acevedo-JakeDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Alexandra GriffithDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Nurten KadincesmeDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Kinga DabekDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Dana HindiDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Ka Kyung KimDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Yoshifumi KobayashiDepartment of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ, 07103, USA.
Emi ShimizuDepartment of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ, 07103, USA.
Vivek KumarDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.

Funding

Growth factors-induced dentinogenesisR01DE025885 · NIDCR · RBHS-SCHOOL OF DENTAL MEDICINE · PI SHIMIZU, EMI · 2016 to 2021
$2.1M
Peptide hydrogels for management and treatment of neovascular posterior segment diseasesR15EY029504 · NEI · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI KUMAR, VIVEK · 2019 to 2020
$508k
NEI NIH HHS R15 EY029504NIDCR NIH HHS R01 DE025885
6 · The paper itself

Abstract

<p class = "Abstract" style = "margin: 0 cm; line-height: 32px; font-size: 12 pt; font-family: "Times New Roman", serif; color: rgb(0, 0, 0); "><span lang = "EN-US">The carious process leads to inflammation of pulp tissue. Current care options include root canal treatment or apexification. These procedures, however, result in the loss of tooth vitality, sensitivity, and healing. Pulp capping and dental pulp regeneration are continually evolving techniques to regenerate pulp tissue, avoiding necrosis and loss of vitality. Many studies have successfully employed stem/progenitor cell populations, revascularization approaches, scaffolds or material-based strategies for pulp regeneration. Here we outline advantages and disadvantages of different methods and techniques which are currently being used in the field of regenerative endodontics. We also summarize recent findings on efficacious peptide-based materials which target the dental niche.<o:p></o:p></span></p>.

Indexed as

Pulp regenerationRegenerative endodonticsScaffoldsStem cellsTissue engineering

Identifiers

PMID35310358
PMCPMC8897646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.