Evidence map›Paper›PMID 35310350›Full record

ArticleBioactive materials2022

2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy.

Yunjie Xu, Yingwei Wang, Jusung An, Adam C Sedgwick, Mingle Li, Jianlei Xie, Weibin Hu, Jianlong Kang, Sajal Sen, Axel Steinbrueck and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. The Emerging Role of MXenes in Cancer Treatment.International journal of molecular sciences · 2025
    Review
  6. Article
  7. TiDrug delivery and translational research · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Novel photodynamic therapy using two-dimensional NiPSNanophotonics (Berlin, Germany) · 2023
    Article
  14. Copper decorated TiNanophotonics (Berlin, Germany) · 2022
    Article
  15. Review
  16. Photoredox catalysis may be a general mechanism in photodynamic therapy.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Yunjie XuShenzhen Engineering Laboratory of Phosphorene and Optoelectronics; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Shenzhen Institute of Translational Medicine, Department of Otolaryngology, Shenzhen Second People's Hospital, The First Affiliated Hospital, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Yingwei WangHunan Key Laboratory of Nanophotonics and Devices, School of Physics and Electronics, Central South University, 932 South Lushan Road, Changsha, 410083, China.
Jusung AnDepartment of Chemistry, Korea University, Seoul, 02841, South Korea.
Adam C SedgwickDepartment of Chemistry, The University of Texas at Austin, Austin, TX, 78712-1224, USA.
Mingle LiDepartment of Chemistry, Korea University, Seoul, 02841, South Korea.
Jianlei XieShenzhen Engineering Laboratory of Phosphorene and Optoelectronics; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Shenzhen Institute of Translational Medicine, Department of Otolaryngology, Shenzhen Second People's Hospital, The First Affiliated Hospital, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Weibin HuDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, 518020, China.
Jianlong KangShenzhen Engineering Laboratory of Phosphorene and Optoelectronics; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Shenzhen Institute of Translational Medicine, Department of Otolaryngology, Shenzhen Second People's Hospital, The First Affiliated Hospital, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Sajal SenDepartment of Chemistry, The University of Texas at Austin, Austin, TX, 78712-1224, USA.
Axel SteinbrueckDepartment of Chemistry, The University of Texas at Austin, Austin, TX, 78712-1224, USA.
Bin ZhangInstitute of Translation Medicine Shenzhen Second People's Hospital First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.
Lijun QiaoDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, 518020, China.
Swelm WagehDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Jonathan F ArambulaDepartment of Chemistry, The University of Texas at Austin, Austin, TX, 78712-1224, USA.
Liping LiuDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, 518020, China.
Han ZhangShenzhen Engineering Laboratory of Phosphorene and Optoelectronics; International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Shenzhen Institute of Translational Medicine, Department of Otolaryngology, Shenzhen Second People's Hospital, The First Affiliated Hospital, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin, Austin, TX, 78712-1224, USA.
Jong Seung KimDepartment of Chemistry, Korea University, Seoul, 02841, South Korea.
The University of Texas at Austin · USKorea University · KRShenzhen Second People's Hospital · CNJinan University · CNCentral South University · CNKing Abdulaziz University · SA

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
NCI NIH HHS R01 CA068682
6 · The paper itself

Abstract

An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target. Unfortunately, current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities. We report here a dual-therapeutic prodrug,

Indexed as

2D MXeneIron chelationNanomedicinePhotothermal therapyProdrug

Identifiers

PMID35310350
PMCPMC8892152
OpenAlexW4200003914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.