Evidence map›Paper›PMID 35310345›Full record

ArticleBioactive materials2022

An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation.

Jing Chen, Julia S Caserto, Ida Ang, Kaavian Shariati, James Webb, Bo Wang, Xi Wang, Nikolaos Bouklas, Minglin Ma

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 52 citations in OpenAlex.

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  14. Hydrogels for Mucosal Drug Delivery.ACS applied bio materials · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jing ChenCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Julia S CasertoRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA.
Ida AngSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA.
Kaavian ShariatiDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.
James WebbDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.
Bo WangDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.
Xi WangDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.
Nikolaos BouklasSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA.
Minglin MaDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.
Cornell University · USNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, to be effective, the hydrogels must have sufficient tissue adhesiveness, tough mechanical property, tunable biodegradability and ideally are easy to apply and form. Herein, we report an adhesive and resilient hydrogel for the sealing and treatment of gastric perforation. The hydrogel consists of a bioactive, transglutaminase (TG)-crosslinked gelatin network and a dynamic, borate-crosslinked poly-N-[Tris(hydroxymethyl)methyl]acrylamide (PTH) network. The hydrogel can be formed

Indexed as

Adhesive hydrogel plugGastric perforationRegenerationThermo-responsive

Identifiers

PMID35310345
PMCPMC8892218
OpenAlexW4200492485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.