Evidence map›Paper›PMID 35310342›Full record

ArticleBioactive materials2022

Polymeric coating lubricates nanocontainers to escape macrophage uptake for bioreceptor recognition.

Yulong Sun, Yanxin Han, Yannong Dou, Xinqi Gong, Haimang Wang, Xiaoyu Yu, Qiang Wang, Yixin Wang, Yue Dai, Fangfu Ye and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yulong SunState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Yanxin HanDepartment of Cardiovascular Medicine, Heart Failure Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Yannong DouDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
Xinqi GongInstitute for Mathematical Sciences, Renmin University of China, Beijing, 100872, China.
Haimang WangState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Xiaoyu YuLab of Soft Matter and Biological Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.
Qiang WangState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Yixin WangState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Yue DaiDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
Fangfu YeLab of Soft Matter and Biological Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.
Wei JinDepartment of Cardiovascular Medicine, Heart Failure Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hongyu ZhangState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate drug delivery to the lesion has been deliberated for several decades, but one important phenomenon is usually neglected that the immune system can prevent smooth transportation of nanomedicine. Although injection would reduce first-pass effect, macrophages in the blood can still recognize and phagocytose nanomedicine. Here we show that a lubricated nanocontainer, which is prepared based on polyelectrolytes and mesoporous silica nanoparticles, can accurately target muscarinic bioreceptor while escaping from the identification of macrophages. Through

Indexed as

Drug deliveryLubricationMacrophage escapeMesoporous silica nanoparticlesPolyelectrolytes

Identifiers

PMID35310342
PMCPMC8892157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.