ArticleiScience2022
Longevity interventions temporally scale healthspan in
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review.Frontiers in aging · 2023Pooled it
- Longevity inbioRxiv : the preprint server for biology · 2026Article
- A multi-ingredient food supplement slows age-dependent decline of mobility and influences gene expression in C. elegans.Biogerontology · 2026Article
- Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging.bioRxiv : the preprint server for biology · 2026Article
- Autophagy: A Double-Edged Sword in the Aging ofInternational journal of molecular sciences · 2026Review
- Slowed Gompertzian ageing in long-lived C. elegans results from expansion of decrepitude, not decelerated ageing.Nature communications · 2026Article
- Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators.Aging cell · 2026Article
- The Strehler-Mildvan mortality correlation arises from changes in the variability of ageing.bioRxiv : the preprint server for biology · 2026Article
- Hematopoietic (stem) cells-The elixir of life?FEBS letters · 2026Review
- Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach.GeroScience · 2026Article
- Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila.npj aging · 2025Article
- A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo.npj aging · 2025Article
- Automated Platforms inMicromachines · 2025Review
- Beyond genes and environment: mapping biological stochasticity in aging.GeroScience · 2025Review
- Compression of morbidity by interventions that steepen the survival curve.Nature communications · 2025Article
- Similarities and differences in the gene expression signatures of physiological age versus future lifespan.Aging cell · 2025Article
- Determination of health status during aging using bending and pumping rates at various survival rates in Caenorhabditis elegans.Scientific reports · 2025Article
- Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age.GeroScience · 2024Article
- Timut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity.Nutrients · 2024Article
- In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes.GeroScience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of morbidity,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.