Evidence map›Paper›PMID 35310241›Full record

ArticleFrontiers in psychology2022

Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network.

Layla Banihashemi, Christine W Peng, Anusha Rangarajan, Helmet T Karim, Meredith L Wallace, Brandon M Sibbach, Jaspreet Singh, Mark M Stinley, Anne Germain, Howard J Aizenstein

Abstract read
In one paragraph

Article in Frontiers in psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Brain and cardiovascular responses to acute stress in remitted and recurrent late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  5. Article
  6. Allostasis, health, and development in Latin America.Neuroscience and biobehavioral reviews · 2024
    Review
  7. Article
  8. Neural circuits regulating visceral pain.Communications biology · 2024
    Review
  9. Article
  10. Glutamatergic and GABAergic anteroventral BNST projections to PVN CRH neurons regulate maternal separation-induced visceral pain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Layla BanihashemiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Christine W PengDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Anusha RangarajanDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Helmet T KarimDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Meredith L WallaceDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Brandon M SibbachDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Jaspreet SinghDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States.
Mark M StinleyDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United States.
Anne GermainDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Howard J AizensteinDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.

Funding

Visceral neural circuits linking childhood threat and deprivation with stress physiology and affective symptoms in a transdiagnostic sample using high-field personalized brain mappingR01MH120065 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BANIHASHEMI, LAYLA · 2019 to 2023
$2.2M
Childhood adversity and central visceral circuits: mechanisms of affective riskK01MH102406 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BANIHASHEMI, LAYLA · 2014 to 2017
$629k
NIMH NIH HHS K01 MH102406NIMH NIH HHS R01 MH120065
6 · The paper itself

Abstract

Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and the resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females (

Indexed as

affective disordersamygdalabed nucleus of stria terminalischildhood traumaextended amygdalahypothalamussubgenual anterior cingulate cortex

Identifiers

PMID35310241
PMCPMC8927539

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.