ArticleFrontiers in neuroscience2022
Identifying Changes of Brain Regional Homogeneity and Cingulo-Opercular Network Connectivity in First-Episode, Drug-Naïve Depressive Patients With Suicidal Ideation.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Treatment-related topological reorganization of the structural connectome in major depressive disorder with suicidal ideation.BMC psychiatry · 2026Article
- Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project.Translational psychiatry · 2025Article
- Structural brain changes in the anterior cingulate cortex of major depressive disorder individuals with suicidal ideation: Evidence from the REST-meta-MDD project.Psychological medicine · 2025Article
- Biomarkers of Suicidal Ideation in Depression: Insights From VMHC Analysis and Machine Learning.Neuropsychiatric disease and treatment · 2025Article
- Abnormal structural covariance network in major depressive disorder: Evidence from the REST-meta-MDD project.NeuroImage. Clinical · 2025Article
- The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men.Biosafety and health · 2024Article
- Connectome architecture modulates the gray matter atrophy in major depression disorder patients with diverse suicidal ideations.Brain imaging and behavior · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Adult patients with major depressive disorder (MDD) may not actively reveal their suicidal ideation (SI). Therefore, this study is committed to finding the alterations in the cingulo-opercular network (CON) that are closely related to SI with multi-imaging methods, thus providing neuroimaging basis for SI. Method: A total of 198 participants (129 MDD patients and 69 healthy controls) were recruited and evaluated with the Montgomery-Asberg Depression Rating Scale (MADRS). The healthy individuals formed the HC group, while the MDD patients were subdivided into no SI MDD (NSI, Results: Compared to those of the HC group, MDD ReHo values and gray matter volume (GMV) were consistently found abnormal in CON. ReHo values and GMV of the right orbital inferior frontal gyrus (ORBinf.R) in the MDD group decreased with the increase of SI. Compared to the HC group, the MDD patients showed enhanced structural connectivity of three pairs of brain regions in CON [ACC.L-left superior frontal gyrus (SFG.L), SFG.L-left middle temporal gyrus (MTG.L), and the SFG.L-left post-central gyrus (PoCG.L)]. Compared with that of the NSI and MSI groups, the structural connectivity of three pairs of brain regions in CON is enhanced in the SSI groups [ORBinf.L-right ventral posterior cingulate gyrus (VPCC.R), VPCC.R-SFG.R, and SFG.R-PoCG.R]. Conclusion: Our findings showed the distinctive ReHo, GMV, and SCN pattern of CON in MDD patients with SI; and with the severity of suicide, abnormal brain regions increased. Our finding suggested that MDD patients with different severity of SI have different neuroimaging changes.
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